DSC3 and PKP4

Number of citations of the paper that reports this interaction (PMID 12615965)
15

Data Source:
HPRD (in vitro, two hybrid)

		DSC3	PKP4
Gene Name		desmocollin 3	plakophilin 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Integral Component Of Membrane Desmosome	Spindle Pole Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Desmosome Midbody Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle
	Molecular Function	Calcium Ion Binding Gamma-catenin Binding	Protein Binding
	Biological Process	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Stabilization	Cell-cell Junction Assembly Cell-cell Signaling Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: CTNNB1 JUP PKP3 PKP4 UCHL5	18 interactors: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBB2IP GABARAP GOLGA2 LNX1 LZTS2 MINK1 OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23
Entrez ID		1825	8502
HPRD ID		02604	05043
Ensembl ID		ENSG00000134762	ENSG00000144283
Uniprot IDs		Q14574	Q99569
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Cell-cell Junction Organization Desmosome Assembly Cellular Response To Indole-3-methanol Desmosome Organization Cell-cell Junction Assembly Single Organismal Cell-cell Adhesion Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Adherens Junction Assembly Cell Adhesion Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Cellular Component Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Protein Heterooligomerization Protein Localization To Plasma Membrane Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Wnt Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Cell-cell Adhesion Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Response To Mechanical Stimulus Skin Development Regulation Of Signal Transduction Plasma Membrane Organization Regulation Of Canonical Wnt Signaling Pathway Establishment Of Protein Localization To Membrane Central Nervous System Vasculogenesis Trachea Formation Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Regulation Of Signaling Negative Regulation Of Protein Sumoylation Positive Regulation Of Branching Involved In Lung Morphogenesis	Cell Adhesion Adherens Junction Organization Single Organismal Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Bundle Of His Cell To Purkinje Myocyte Communication Cell-cell Junction Organization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cellular Component Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cellular Response To Starvation Negative Regulation Of Canonical Wnt Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cellular Response To Nutrient Levels Response To Starvation Cardiovascular System Development Cardiac Muscle Cell Action Potential Negative Regulation Of Wnt Signaling Pathway Autophagic Vacuole Assembly Cell Junction Assembly Regulation Of Protein Ubiquitination Intermediate Filament Cytoskeleton Organization Blood Vessel Development Intermediate Filament-based Process Cellular Response To Extracellular Stimulus Regulation Of Cardiac Muscle Cell Contraction Vasculature Development Cardiac Conduction Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stress Macroautophagy Cajal-Retzius Cell Differentiation Positive Regulation Of Histone H3-K36 Methylation Regulation Of Pentose-phosphate Shunt Beta-amyloid Formation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Membrane Potential Organelle Organization Cytoskeleton Organization Regulation Of Wnt Signaling Pathway Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cellular Component Movement Regulation Of Cardiac Muscle Contraction Threonylcarbamoyladenosine Biosynthetic Process Basal Protein Localization
Tagcloud ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Difference) ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes
Tagcloud (Intersection) ?