DSC3 and PKP4

Number of citations of the paper that reports this interaction (PubMedID 12615965)
0

Data Source:
HPRD (two hybrid, in vitro)

		DSC3	PKP4
Description		desmocollin 3	plakophilin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Cell Junction Desmosome Anchoring Junction	Spindle Pole Cornified Envelope Nucleus Cytoplasm Spindle Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Desmosome Midbody Organelle Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Anchoring Junction Mitotic Spindle
	Molecular Function	Calcium Ion Binding Gamma-catenin Binding Metal Ion Binding	Protein Binding Cadherin Binding
	Biological Process	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Stabilization Cell-cell Adhesion	Cell-cell Junction Assembly Cell Adhesion Cell-cell Signaling Regulation Of Cell Adhesion Positive Regulation Of Cytokinesis Regulation Of Rho Protein Signal Transduction Cell-cell Adhesion
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases		Hypotrichosis and recurrent skin vesicles
GWAS		Bronchopulmonary dysplasia ( 23897914) Hand grip strength (Mahalanobis distance) ( 32235003) Metabolite levels ( 31628463) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Supraventricular ectopy ( 29618737) Type 2 diabetes ( 31049640)	Borderline personality disorder ( 28632202) Obesity-related traits ( 23251661) Restless legs syndrome ( 29029846)
Interacting Genes		5 interacting genes: CTNNB1 JUP PKP3 PKP4 UCHL5	20 interacting genes: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBIN GABARAP GOLGA2 LNX1 LZTS2 MINK1 OGT OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23 UBASH3B
Entrez ID		1825	8502
HPRD ID		02604	05043
Ensembl ID		ENSG00000134762	ENSG00000144283
Uniprot IDs		Q14574	Q99569
PDB IDs
Enriched GO Terms of Interacting Partners?		Desmosome Adherens Junction Cornified Envelope Alpha-catenin Binding Cell-cell Junction Assembly Anchoring Junction Cell-cell Junction Organization Cell-cell Adhesion Catenin-TCF7L2 Complex Intercalated Disc Cell-cell Junction Cell Junction Cellular Response To Indole-3-methanol Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cell Junction Assembly Response To Indole-3-methanol Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Cadherin Binding Cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Cell Junction Organization Epithelial Cell-cell Adhesion Catenin Complex Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Midbrain Development Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Regulation Of Cell Adhesion Cardiac Conduction Skin Development Regulation Of Action Potential Homotypic Cell-cell Adhesion Positive Regulation Of Telomere Maintenance Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Gamma-catenin-TCF7L2 Complex Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction Regulation Of Embryonic Development Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex	Desmosome Cell Junction Cell Adhesion Gamma-catenin Binding Adherens Junction Organization Cell-cell Adhesion Cell-cell Junction Catenin Complex Beta-catenin Binding Anchoring Junction Intracellular Protein Localization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Mediated By Cadherin Cell Junction Organization Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cytoplasm Cadherin Binding Fascia Adherens Cell-cell Junction Organization Adherens Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Postsynapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synapse Organization Protein Localization To Cell-cell Junction Smooth Endoplasmic Reticulum Brain Morphogenesis Regulation Of Cellular Localization Cell-cell Junction Assembly Regulation Of Protein Localization To Synapse Regulation Of Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Receptor Localization To Synapse Plasma Membrane Protein Glycosylation Macromolecule Glycosylation Regulation Of Rac Protein Signal Transduction Cell-cell Adhesion Mediator Activity Regulation Of Protein Localization To Nucleus Cytoskeleton Organization Glycosylation Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus Protein Tyrosine Kinase Binding Cellular Component Assembly Regulation Of Protein Localization To Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Core Promoter Binding Protein N-acetylglucosaminyltransferase Complex
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