PCSK5 and APPBP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PCSK5	APPBP2
Gene Name		proprotein convertase subtilisin/kexin type 5	amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Apparatus Golgi Lumen Integral Component Of Membrane Secretory Granule	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Peptide Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Proteolysis Cell-cell Signaling Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Cytokine Biosynthetic Process Peptide Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Embryonic Digestive Tract Development Embryonic Skeletal System Development	Intracellular Protein Transport Metabolic Process Intracellular Transport
Pathways		Signalling by NGF NGF processing
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Height ( 20881960 23563607) Metabolite levels (5-HIAA) ( 23319000) Response to fenofibrate (adiponectin levels) ( 23149075) Total ventricular volume ( 21116278)
Protein-Protein Interactions		20 interactors: AMH APPBP2 ATN1 CACNA1A GLRX3 HOXA1 ITGA6 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 KRTAP5-9 LCE3C MEOX2 NOTCH2NL NUFIP2 PMCH PTPRM REN STK16	79 interactors: AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 DCD DHRS2 DPEP1 EID3 EPT1 ERO1L FAM19A4 FAM92A1 FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 HIPK4 HIST1H2AK HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MGC34796 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		5125	10513
HPRD ID		08985	05616
Ensembl ID		ENSG00000099139	ENSG00000062725
Uniprot IDs		Q92824	Q92624
PDB IDs
Enriched GO Terms of Interacting Partners?		Developmental Process Multicellular Organismal Development Pons Development Cell Differentiation Anatomical Structure Development Organ Development System Development Tissue Development Behavior Neural Nucleus Development Optokinetic Behavior Cerebellar Molecular Layer Development Abducens Nerve Formation Neuron Death Vestibular Nucleus Development Facial Nucleus Development Preantral Ovarian Follicle Growth Urogenital System Development Feeding Behavior Positive Regulation Of Gene Expression Rhombomere 4 Development Cerebellum Maturation Semicircular Canal Formation Musculoskeletal Movement, Spinal Reflex Action Anatomical Structure Morphogenesis Rhombomere 3 Development Rhombomere 5 Development Gamma-aminobutyric Acid Secretion Renin-angiotensin Regulation Of Aldosterone Production Metencephalon Development Neuromuscular Process Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Response To Drug Rhythmic Synaptic Transmission Somite Specification Ectodermal Cell Differentiation Cell Development Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Oogenesis Stage Cell Projection Organization Drinking Behavior Gonadal Mesoderm Development Response To CGMP Mullerian Duct Regression Hindbrain Development Cell Morphogenesis Involved In Neuron Differentiation Calcium Ion-dependent Exocytosis Of Neurotransmitter	Regulation Of Defense Response To Virus By Host Response To Stress Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Homocysteine Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Difference) ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Intersection) ?