PCSK5 and ATN1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PCSK5	ATN1
Gene Name		proprotein convertase subtilisin/kexin type 5	atrophin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Apparatus Golgi Lumen Integral Component Of Membrane Secretory Granule	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Peptide Binding	Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Toxin Receptor Binding
	Biological Process	Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Proteolysis Cell-cell Signaling Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Cytokine Biosynthetic Process Peptide Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Embryonic Digestive Tract Development Embryonic Skeletal System Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Central Nervous System Development Toxin Metabolic Process Cell Migration Maintenance Of Cell Polarity Neuron Apoptotic Process
Pathways		Signalling by NGF NGF processing
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Height ( 20881960 23563607) Metabolite levels (5-HIAA) ( 23319000) Response to fenofibrate (adiponectin levels) ( 23149075) Total ventricular volume ( 21116278)
Protein-Protein Interactions		20 interactors: AMH APPBP2 ATN1 CACNA1A GLRX3 HOXA1 ITGA6 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 KRTAP5-9 LCE3C MEOX2 NOTCH2NL NUFIP2 PMCH PTPRM REN STK16	93 interactors: AES AGRN ALG13 ARF3 ATRX BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CTNND2 DMPK DVL1 DVL2 ECM1 EFEMP1 EFEMP2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HINFP HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP4-12 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 PCSK5 PDCD6IP PFKL PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SIAH1 SIAH2 SLIT1 SPAG5 SSPO STXBP4 SYVN1 TEP1 TLE1 TRIP6 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZSWIM8
Entrez ID		5125	1822
HPRD ID		08985	06311
Ensembl ID		ENSG00000099139	ENSG00000111676
Uniprot IDs		Q92824	P54259 Q86V38
PDB IDs
Enriched GO Terms of Interacting Partners?		Developmental Process Multicellular Organismal Development Pons Development Cell Differentiation Anatomical Structure Development Organ Development System Development Tissue Development Behavior Neural Nucleus Development Optokinetic Behavior Cerebellar Molecular Layer Development Abducens Nerve Formation Neuron Death Vestibular Nucleus Development Facial Nucleus Development Preantral Ovarian Follicle Growth Urogenital System Development Feeding Behavior Positive Regulation Of Gene Expression Rhombomere 4 Development Cerebellum Maturation Semicircular Canal Formation Musculoskeletal Movement, Spinal Reflex Action Anatomical Structure Morphogenesis Rhombomere 3 Development Rhombomere 5 Development Gamma-aminobutyric Acid Secretion Renin-angiotensin Regulation Of Aldosterone Production Metencephalon Development Neuromuscular Process Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Response To Drug Rhythmic Synaptic Transmission Somite Specification Ectodermal Cell Differentiation Cell Development Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Oogenesis Stage Cell Projection Organization Drinking Behavior Gonadal Mesoderm Development Response To CGMP Mullerian Duct Regression Hindbrain Development Cell Morphogenesis Involved In Neuron Differentiation Calcium Ion-dependent Exocytosis Of Neurotransmitter	Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Developmental Process Regulation Of Gene Expression Signaling Regulation Of Signaling Signal Transduction Nervous System Development Anatomical Structure Development Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Proteolysis Regulation Of RNA Biosynthetic Process System Development Response To Stimulus Cell Death Death Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Morphogenesis Modification-dependent Protein Catabolic Process Protein Catabolic Process Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Programmed Cell Death Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Biosynthetic Process Protein Ubiquitination Axon Development
Tagcloud ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	atrophin1 atrophy chip cortical degenerative demethylase dentatorubral depletion h3k4 hint inducing knockout lbal lsd1 lysine maintenance methylation npc pallidoluysian phenocopied poorly precise premature progenitor repression rescued seq surprisingly tranylcypromine
Tagcloud (Difference) ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	atrophin1 atrophy chip cortical degenerative demethylase dentatorubral depletion h3k4 hint inducing knockout lbal lsd1 lysine maintenance methylation npc pallidoluysian phenocopied poorly precise premature progenitor repression rescued seq surprisingly tranylcypromine
Tagcloud (Intersection) ?