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ABI3 and WAS
Number of citations of the paper that reports this interaction (PubMedID
21516116
)
20
Data Source:
BioGRID
(two hybrid)
ABI3
WAS
Description
ABI family member 3
WASP actin nucleation promoting factor
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Postsynaptic Density
Membrane
Lamellipodium
SCAR Complex
Dendritic Spine
Dendritic Shaft
Postsynapse
Actin-based Cell Projection
Glutamatergic Synapse
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Vesicle Membrane
Actin Cytoskeleton
Membrane
Site Of Double-strand Break
Phagocytic Vesicle
Extracellular Exosome
Molecular Function
Protein Binding
Signaling Adaptor Activity
Identical Protein Binding
Actin Filament Binding
Actin Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
GTPase Regulator Activity
Small GTPase Binding
Identical Protein Binding
Phospholipase Binding
Biological Process
Neuron Migration
Defense Response To Tumor Cell
Negative Regulation Of Lamellipodium Assembly
Peptidyl-tyrosine Phosphorylation
Actin Cytoskeleton Organization
Regulation Of Cell Migration
Cell Projection Morphogenesis
Regulation Of Dendritic Spine Morphogenesis
Modification Of Postsynaptic Actin Cytoskeleton
Regulation Of Postsynaptic Density Assembly
Negative Regulation Of Ruffle Assembly
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cellular Senescence
Regulation Of T Cell Antigen Processing And Presentation
Defense Response
Immune Response
Actin Filament Organization
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Actin Polymerization Or Depolymerization
Actin Polymerization Or Depolymerization
Epidermis Development
Regulation Of Lamellipodium Assembly
Endosomal Transport
Actin Filament Polymerization
Actin Filament-based Movement
Cdc42 Protein Signal Transduction
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Protein-containing Complex Assembly
Cellular Response To Type II Interferon
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Cell Motility
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOJ GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Drugs
(S)-wiskostatin
Diseases
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Alzheimer's disease (late onset) (
28714976
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Asthma (
31619474
)
Family history of Alzheimer's disease (
30617256
)
Prostate cancer (
23535732
)
Refractive error (
32231278
)
Platelet distribution width (
32888494
)
Interacting Genes
77 interacting genes:
ABI2
ABI3BP
ACTN3
AGTR1
ARHGAP9
ARMC7
BAIAP2L2
BFSP2
BLOC1S5
CENPQ
CEP170P1
CEP44
CYFIP2
DESI1
DTNB
DTNBP1
EIF3H
EIF3M
EMILIN1
ENAH
EVL
FAM124B
FARSA
FBF1
GNG13
GOLM1
GRB2
HOMER1
HOMER2
HOMER3
IFT20
IHO1
KANK2
KIAA0408
KIFC3
KLC3
KLC4
KRT13
KRT14
KRT15
KRT24
KRT28
KRT31
KRT35
KRT36
KRT38
MAGEA12
MED29
MIS18A
MRFAP1
MRFAP1L1
NCK2
NDEL1
NHSL2
NUP58
OIP5
PAK1
PAK2
PSMA1
RUFY3
RUNX1T1
SH3BP1
SMARCD1
SNAP23
SOS1
STX1A
STX2
SUFU
TMEM147
TRAF4
TXN2
VARS2
VASP
WAS
WASF1
WASF2
WASHC1
61 interacting genes:
ABI3
ACTC1
ACTR2
APBB1
APPBP2
ARHGAP1
ARHGEF7
ARPC1B
ARPC2
ARPC3
BAIAP2L1
BTK
C5AR1
CDC42
CIB1
CREBBP
CRKL
CSNK2A1
CSNK2A2
DLG1
DVL2
ENAH
EVL
FCHSD2
FGR
FYB1
FYN
GRB2
HCK
HCLS1
ITK
ITSN2
LCK
LCP2
NCK1
NCK2
NCKIPSD
PIK3R1
PLCG1
PRPF40A
PSTPIP1
PTPN12
RAC1
RANBP2
RGS14
RHOJ
RPA1
RPA2
RPA3
SNX9
SORBS2
SRC
TCERG1
TEC
TNK2
TRIP10
UBASH3A
VASP
WBP4
WIPF1
WIPF2
Entrez ID
51225
7454
HPRD ID
05900
02314
Ensembl ID
ENSG00000108798
ENSG00000015285
Uniprot IDs
Q9P2A4
A0A8V8TM35
P42768
PDB IDs
1CEE
1EJ5
1T84
2A3Z
2K42
2OT0
Enriched GO Terms of Interacting Partners
?
Supramolecular Fiber Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Regulation Of Actin Filament Organization
Intermediate Filament Organization
Structural Constituent Of Skin Epidermis
Keratin Filament
Regulation Of Actin Cytoskeleton Organization
Cytoskeleton
Regulation Of Actin Filament-based Process
Regulation Of Supramolecular Fiber Organization
Structural Molecule Activity
SH3 Domain Binding
Anatomical Structure Morphogenesis
Morphogenesis Of An Epithelium
Intermediate Filament
Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Lamellipodium
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Actin Filament Organization
Tissue Morphogenesis
Positive Regulation Of Supramolecular Fiber Organization
G Protein-coupled Glutamate Receptor Binding
SCAR Complex
Positive Regulation Of Cytoskeleton Organization
Organelle Organization
Actin Polymerization Or Depolymerization
Cytosol
Regulation Of Actin Filament Polymerization
Epithelial Cell Differentiation
Anchoring Junction
Regulation Of Cellular Component Size
Protein Binding
Positive Regulation Of Protein Polymerization
Positive Regulation Of Actin Filament Polymerization
Cellular Component Assembly
Positive Regulation Of Cellular Component Biogenesis
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Profilin Binding
Developmental Process
Regulation Of Organelle Organization
Regulation Of Actin Nucleation
Postsynaptic Density
Vesicle Membrane
Cell Projection Organization
Positive Regulation Of Actin Nucleation
Regulation Of Store-operated Calcium Entry
Positive Regulation Of Actin Filament Polymerization
Actin Filament Organization
Regulation Of Actin Filament Polymerization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Positive Regulation Of Protein Polymerization
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Actin Filament Organization
Regulation Of Supramolecular Fiber Organization
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Actin Cytoskeleton Organization
Lamellipodium
Supramolecular Fiber Organization
Immune Response-activating Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Actin Filament-based Process
Regulation Of Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Supramolecular Fiber Organization
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Cytoskeleton Organization
Regulation Of Cellular Component Size
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Component Biogenesis
Cytosol
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Cytoplasm
Regulation Of Lamellipodium Organization
Positive Regulation Of Cellular Component Organization
Focal Adhesion
Positive Regulation Of Immune System Process
Regulation Of Cellular Component Organization
Positive Regulation Of Lamellipodium Organization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Immune Response
Cell Projection
SH3 Domain Binding
Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Organelle Organization
Regulation Of Immune Response
Peptidyl-tyrosine Phosphorylation
Intracellular Signal Transduction
Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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