ABI3 and EIF3M

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABI3	EIF3M
Description		ABI family member 3	eukaryotic translation initiation factor 3 subunit M
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Membrane Lamellipodium SCAR Complex Dendritic Spine Dendritic Shaft Postsynapse Actin-based Cell Projection Glutamatergic Synapse	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Protein Binding Signaling Adaptor Activity Identical Protein Binding Actin Filament Binding	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Neuron Migration Defense Response To Tumor Cell Negative Regulation Of Lamellipodium Assembly Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Regulation Of Cell Migration Cell Projection Morphogenesis Regulation Of Dendritic Spine Morphogenesis Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Postsynaptic Density Assembly Negative Regulation Of Ruffle Assembly Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Senescence	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31619474) Family history of Alzheimer's disease ( 30617256) Prostate cancer ( 23535732) Refractive error ( 32231278)	Menopause (age at onset) ( 26414677) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		77 interacting genes: ABI2 ABI3BP ACTN3 AGTR1 ARHGAP9 ARMC7 BAIAP2L2 BFSP2 BLOC1S5 CENPQ CEP170P1 CEP44 CYFIP2 DESI1 DTNB DTNBP1 EIF3H EIF3M EMILIN1 ENAH EVL FAM124B FARSA FBF1 GNG13 GOLM1 GRB2 HOMER1 HOMER2 HOMER3 IFT20 IHO1 KANK2 KIAA0408 KIFC3 KLC3 KLC4 KRT13 KRT14 KRT15 KRT24 KRT28 KRT31 KRT35 KRT36 KRT38 MAGEA12 MED29 MIS18A MRFAP1 MRFAP1L1 NCK2 NDEL1 NHSL2 NUP58 OIP5 PAK1 PAK2 PSMA1 RUFY3 RUNX1T1 SH3BP1 SMARCD1 SNAP23 SOS1 STX1A STX2 SUFU TMEM147 TRAF4 TXN2 VARS2 VASP WAS WASF1 WASF2 WASHC1	10 interacting genes: ABI3 APP EIF3F EXOSC10 HSPB1 METTL3 SRPK1 TRIML2 ZMYND10 ZNF783
Entrez ID		51225	10480
HPRD ID		05900	09969
Ensembl ID		ENSG00000108798	ENSG00000149100
Uniprot IDs		Q9P2A4	Q7L2H7
PDB IDs			3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Actin Filament Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Keratin Filament Regulation Of Actin Cytoskeleton Organization Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Structural Molecule Activity SH3 Domain Binding Anatomical Structure Morphogenesis Morphogenesis Of An Epithelium Intermediate Filament Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Actin Filament Organization Tissue Morphogenesis Positive Regulation Of Supramolecular Fiber Organization G Protein-coupled Glutamate Receptor Binding SCAR Complex Positive Regulation Of Cytoskeleton Organization Organelle Organization Actin Polymerization Or Depolymerization Cytosol Regulation Of Actin Filament Polymerization Epithelial Cell Differentiation Anchoring Junction Regulation Of Cellular Component Size Protein Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Actin Filament Polymerization Cellular Component Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Profilin Binding Developmental Process Regulation Of Organelle Organization Regulation Of Actin Nucleation Postsynaptic Density Vesicle Membrane Cell Projection Organization Positive Regulation Of Actin Nucleation Regulation Of Store-operated Calcium Entry	Amyloid-beta Complex Innate Immune Response Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Response To Other Organism Identical Protein Binding Protein Folding Chaperone Negative Regulation Of Protein Kinase C Signaling Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Positive Regulation Of Motile Cilium Assembly Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Interleukin-1 Production Regulation Of MRNA Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Translation Regulation Of Protein Import Axo-dendritic Transport Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Microtubule-based Movement Regulation Of Interleukin-1 Beta Production Regulation Of Translational Initiation Protein Kinase C Inhibitor Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Positive Regulation Of Cap-independent Translational Initiation Endothelial To Hematopoietic Transition MRNA M(6)A Methyltransferase Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Interleukin-1 Production Cytoplasm
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