ABI3 and RUFY3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABI3	RUFY3
Description		ABI family member 3	RUN and FYVE domain containing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Membrane Lamellipodium SCAR Complex Dendritic Spine Dendritic Shaft Postsynapse Actin-based Cell Projection Glutamatergic Synapse	Cytoplasm Lysosome Cytosol Endomembrane System Membrane Lamellipodium Filopodium Axon Dendrite Growth Cone Endolysosome Cell Projection Neuronal Cell Body Perikaryon Anchoring Junction
	Molecular Function	Protein Binding Signaling Adaptor Activity Identical Protein Binding Actin Filament Binding	Protein Binding Dynactin Binding
	Biological Process	Neuron Migration Defense Response To Tumor Cell Negative Regulation Of Lamellipodium Assembly Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Regulation Of Cell Migration Cell Projection Morphogenesis Regulation Of Dendritic Spine Morphogenesis Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Postsynaptic Density Assembly Negative Regulation Of Ruffle Assembly Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Senescence	Actin Filament Organization Nervous System Development Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Axon Extension Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Cell Polarity Positive Regulation Of Retrograde Axon Cargo Transport
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31619474) Family history of Alzheimer's disease ( 30617256) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		77 interacting genes: ABI2 ABI3BP ACTN3 AGTR1 ARHGAP9 ARMC7 BAIAP2L2 BFSP2 BLOC1S5 CENPQ CEP170P1 CEP44 CYFIP2 DESI1 DTNB DTNBP1 EIF3H EIF3M EMILIN1 ENAH EVL FAM124B FARSA FBF1 GNG13 GOLM1 GRB2 HOMER1 HOMER2 HOMER3 IFT20 IHO1 KANK2 KIAA0408 KIFC3 KLC3 KLC4 KRT13 KRT14 KRT15 KRT24 KRT28 KRT31 KRT35 KRT36 KRT38 MAGEA12 MED29 MIS18A MRFAP1 MRFAP1L1 NCK2 NDEL1 NHSL2 NUP58 OIP5 PAK1 PAK2 PSMA1 RUFY3 RUNX1T1 SH3BP1 SMARCD1 SNAP23 SOS1 STX1A STX2 SUFU TMEM147 TRAF4 TXN2 VARS2 VASP WAS WASF1 WASF2 WASHC1	7 interacting genes: ABI3 APP ARL8B CAPN3 DSCAM RAB33A UNC119
Entrez ID		51225	22902
HPRD ID		05900	15251
Ensembl ID		ENSG00000108798	ENSG00000018189
Uniprot IDs		Q9P2A4	B4DG59 B4DKC2 Q7L099
PDB IDs
Enriched GO Terms of Interacting Partners?		Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Actin Filament Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Keratin Filament Regulation Of Actin Cytoskeleton Organization Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Structural Molecule Activity SH3 Domain Binding Anatomical Structure Morphogenesis Morphogenesis Of An Epithelium Intermediate Filament Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Actin Filament Organization Tissue Morphogenesis Positive Regulation Of Supramolecular Fiber Organization G Protein-coupled Glutamate Receptor Binding SCAR Complex Positive Regulation Of Cytoskeleton Organization Organelle Organization Actin Polymerization Or Depolymerization Cytosol Regulation Of Actin Filament Polymerization Epithelial Cell Differentiation Anchoring Junction Regulation Of Cellular Component Size Protein Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Actin Filament Polymerization Cellular Component Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Profilin Binding Developmental Process Regulation Of Organelle Organization Regulation Of Actin Nucleation Postsynaptic Density Vesicle Membrane Cell Projection Organization Positive Regulation Of Actin Nucleation Regulation Of Store-operated Calcium Entry	Amyloid-beta Complex Cell Projection Morphogenesis Dendritic Shaft Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Recognition Synaptic Signaling Synapse Synapse Organization Calcium-dependent Self Proteolysis Spindle Midzone Antigen Processing And Presentation Following Phagocytosis Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Viral Exocytosis Axo-dendritic Transport Acetylcholine Receptor Activator Activity Lipoprotein Particle Cell Junction Organization Positive Regulation Of Protein Import Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Negative Regulation Of Caveolin-mediated Endocytosis Antigen Processing And Presentation Endosome To Lysosome Transport Of Low-density Lipoprotein Particle PTB Domain Binding Regulation Of Phosphorus Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Calcium Ion Regulated Lysosome Exocytosis Protein Localization To Early Endosome Cell-cell Signaling Regulation Of Growth
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