ABI3 and ENAH

Number of citations of the paper that reports this interaction (PMID 17101133)
6

Data Source:
HPRD (in vivo)

		ABI3	ENAH
Gene Name		ABI family, member 3	enabled homolog (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Membrane Lamellipodium	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse
	Molecular Function	Protein Binding	Actin Binding Protein Binding SH3 Domain Binding WW Domain Binding
	Biological Process	Movement Of Cell Or Subcellular Component Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Intracellular Transport T Cell Receptor Signaling Pathway
Pathways			TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		36 interactors: ABI3BP ACTN3 ARMC7 CEP170P1 CEP44 CYFIP2 DTNB DTNBP1 EIF3H ENAH EVL FARSA FBF1 GRB2 HOMER1 HOMER3 KANK2 KIAA0408 KLC3 KLC4 KRT13 KRT15 MAGEA12 MRFAP1L1 NCK2 NUPL1 PAK1 PAK2 PSMA1 RUNX1T1 SNAP23 SOS1 TMEM147 VASP WAS WASF2	20 interactors: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP FAT1 FYB GPHN MAPK1 PFN1 PRPF40A ROBO4 SPTA1 TERF2IP TES WAS XIRP1 ZYX
Entrez ID		51225	55740
HPRD ID		05900	12360
Ensembl ID		ENSG00000108798	ENSG00000154380
Uniprot IDs		Q9P2A4	Q8N8S7
PDB IDs			2HO2 2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Immune Response-regulating Signaling Pathway Movement Of Cell Or Subcellular Component Axon Guidance Cell Morphogenesis Fc Receptor Signaling Pathway Neuron Projection Morphogenesis Actin Filament-based Process Cell Projection Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytoskeleton Organization Axonogenesis Regulation Of Actin Cytoskeleton Organization T Cell Receptor Signaling Pathway Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Chemotaxis Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Neuron Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Immune System Process Actin Polymerization Or Depolymerization Immune System Process Neuron Differentiation Cytoskeleton Organization Cell Development Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Phagocytosis Actin Filament Organization Innate Immune Response	Actin Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Development Cell Projection Organization Actin Polymerization Or Depolymerization Neuron Projection Development Locomotion Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Regulation Of Immune System Process Cell Development Axonogenesis Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation T Cell Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cell Motility Neuron Projection Morphogenesis System Development Regulation Of Response To DNA Damage Stimulus Cell Morphogenesis Endocytosis Regulation Of Actin Nucleation
Tagcloud ?		abbreviated cfp chose clustered confirming cotyledons derepressing detail egfp embryo embryogenesis embryos exemplified files fus3 germinating germinative globular heterochronic lec lec1 lec2 misexpression pyk10 reporter repressing seedling seedlings stochastic	atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation
Tagcloud (Difference) ?		abbreviated cfp chose clustered confirming cotyledons derepressing detail egfp embryo embryogenesis embryos exemplified files fus3 germinating germinative globular heterochronic lec lec1 lec2 misexpression pyk10 reporter repressing seedling seedlings stochastic	atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation
Tagcloud (Intersection) ?