ABI3 and FARSA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ABI3	FARSA
Description		ABI family member 3	phenylalanyl-tRNA synthetase subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Membrane Lamellipodium SCAR Complex Dendritic Spine Dendritic Shaft Postsynapse Actin-based Cell Projection Glutamatergic Synapse	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane
	Molecular Function	Protein Binding Signaling Adaptor Activity Identical Protein Binding Actin Filament Binding	TRNA Binding Nucleotide Binding Magnesium Ion Binding RNA Binding Aminoacyl-tRNA Ligase Activity Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding
	Biological Process	Neuron Migration Defense Response To Tumor Cell Negative Regulation Of Lamellipodium Assembly Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Regulation Of Cell Migration Cell Projection Morphogenesis Regulation Of Dendritic Spine Morphogenesis Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Postsynaptic Density Assembly Negative Regulation Of Ruffle Assembly Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Senescence	Translation Phenylalanyl-tRNA Aminoacylation TRNA Aminoacylation Protein Heterotetramerization
Pathways			Cytosolic tRNA aminoacylation
Drugs			Phenylalanine
Diseases
GWAS		Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31619474) Family history of Alzheimer's disease ( 30617256) Prostate cancer ( 23535732) Refractive error ( 32231278)	Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Type 2 diabetes ( 30297969)
Interacting Genes		77 interacting genes: ABI2 ABI3BP ACTN3 AGTR1 ARHGAP9 ARMC7 BAIAP2L2 BFSP2 BLOC1S5 CENPQ CEP170P1 CEP44 CYFIP2 DESI1 DTNB DTNBP1 EIF3H EIF3M EMILIN1 ENAH EVL FAM124B FARSA FBF1 GNG13 GOLM1 GRB2 HOMER1 HOMER2 HOMER3 IFT20 IHO1 KANK2 KIAA0408 KIFC3 KLC3 KLC4 KRT13 KRT14 KRT15 KRT24 KRT28 KRT31 KRT35 KRT36 KRT38 MAGEA12 MED29 MIS18A MRFAP1 MRFAP1L1 NCK2 NDEL1 NHSL2 NUP58 OIP5 PAK1 PAK2 PSMA1 RUFY3 RUNX1T1 SH3BP1 SMARCD1 SNAP23 SOS1 STX1A STX2 SUFU TMEM147 TRAF4 TXN2 VARS2 VASP WAS WASF1 WASF2 WASHC1	13 interacting genes: A2M ABI3 APOE COG4 CRIPTO ECSIT ESR1 GORAB HNRNPR OGT PDCD10 PTEN RNF32
Entrez ID		51225	2193
HPRD ID		05900	04227
Ensembl ID		ENSG00000108798	ENSG00000179115
Uniprot IDs		Q9P2A4	Q6IBR2 Q9Y285
PDB IDs			3L4G
Enriched GO Terms of Interacting Partners?		Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Actin Filament Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Keratin Filament Regulation Of Actin Cytoskeleton Organization Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Structural Molecule Activity SH3 Domain Binding Anatomical Structure Morphogenesis Morphogenesis Of An Epithelium Intermediate Filament Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Actin Filament Organization Tissue Morphogenesis Positive Regulation Of Supramolecular Fiber Organization G Protein-coupled Glutamate Receptor Binding SCAR Complex Positive Regulation Of Cytoskeleton Organization Organelle Organization Actin Polymerization Or Depolymerization Cytosol Regulation Of Actin Filament Polymerization Epithelial Cell Differentiation Anchoring Junction Regulation Of Cellular Component Size Protein Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Actin Filament Polymerization Cellular Component Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Profilin Binding Developmental Process Regulation Of Organelle Organization Regulation Of Actin Nucleation Postsynaptic Density Vesicle Membrane Cell Projection Organization Positive Regulation Of Actin Nucleation Regulation Of Store-operated Calcium Entry	Negative Regulation Of Cell Migration Regulation Of Cell Migration Lipid Binding Regulation Of Locomotion Negative Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Oxidoreductase Activity Negative Regulation Of Locomotion Enzyme Binding Regulation Of Innate Immune Response Positive Regulation Of Proteolysis Negative Regulation Of Phospholipid Efflux Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Anatomical Structure Morphogenesis Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Metal Chelating Activity Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Cell Projection Organization Intermediate-density Lipoprotein Particle Clearance Regulation Of Catalytic Activity Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cellular Senescence Regulation Of Phosphorus Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of MAP Kinase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Endothelial Cell Proliferation Cellular Component Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Rhythmic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Junction Assembly Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Negative Regulation Of Complement Activation, Lectin Pathway
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