ABI3 and NUP58

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABI3	NUP58
Description		ABI family member 3	nucleoporin 58
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Membrane Lamellipodium SCAR Complex Dendritic Spine Dendritic Shaft Postsynapse Actin-based Cell Projection Glutamatergic Synapse	Nucleus Nuclear Envelope Nuclear Pore Membrane Nuclear Membrane Protein-containing Complex
	Molecular Function	Protein Binding Signaling Adaptor Activity Identical Protein Binding Actin Filament Binding	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Neuron Migration Defense Response To Tumor Cell Negative Regulation Of Lamellipodium Assembly Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Regulation Of Cell Migration Cell Projection Morphogenesis Regulation Of Dendritic Spine Morphogenesis Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Postsynaptic Density Assembly Negative Regulation Of Ruffle Assembly Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Senescence	Nucleocytoplasmic Transport Protein Transport Regulation Of Protein Import Into Nucleus MRNA Transport
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31619474) Family history of Alzheimer's disease ( 30617256) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		77 interacting genes: ABI2 ABI3BP ACTN3 AGTR1 ARHGAP9 ARMC7 BAIAP2L2 BFSP2 BLOC1S5 CENPQ CEP170P1 CEP44 CYFIP2 DESI1 DTNB DTNBP1 EIF3H EIF3M EMILIN1 ENAH EVL FAM124B FARSA FBF1 GNG13 GOLM1 GRB2 HOMER1 HOMER2 HOMER3 IFT20 IHO1 KANK2 KIAA0408 KIFC3 KLC3 KLC4 KRT13 KRT14 KRT15 KRT24 KRT28 KRT31 KRT35 KRT36 KRT38 MAGEA12 MED29 MIS18A MRFAP1 MRFAP1L1 NCK2 NDEL1 NHSL2 NUP58 OIP5 PAK1 PAK2 PSMA1 RUFY3 RUNX1T1 SH3BP1 SMARCD1 SNAP23 SOS1 STX1A STX2 SUFU TMEM147 TRAF4 TXN2 VARS2 VASP WAS WASF1 WASF2 WASHC1	19 interacting genes: ABI3 AGR2 APC COG3 COG6 HTT KRT27 KRT28 KRT33B MAPK3 MEIS2 MIS18A NUP62 PKNOX1 PKNOX2 TRAF1 TRIM54 UBQLN1 UBQLN2
Entrez ID		51225	9818
HPRD ID		05900	06355
Ensembl ID		ENSG00000108798	ENSG00000139496
Uniprot IDs		Q9P2A4	A0A8Q3WKK5 A0A8Q3WKL7 Q9BVL2
PDB IDs			4JO7 4JO9 4JQ5 5IJN 5IJO 7PER 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Actin Filament Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Keratin Filament Regulation Of Actin Cytoskeleton Organization Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Structural Molecule Activity SH3 Domain Binding Anatomical Structure Morphogenesis Morphogenesis Of An Epithelium Intermediate Filament Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Actin Filament Organization Tissue Morphogenesis Positive Regulation Of Supramolecular Fiber Organization G Protein-coupled Glutamate Receptor Binding SCAR Complex Positive Regulation Of Cytoskeleton Organization Organelle Organization Actin Polymerization Or Depolymerization Cytosol Regulation Of Actin Filament Polymerization Epithelial Cell Differentiation Anchoring Junction Regulation Of Cellular Component Size Protein Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Actin Filament Polymerization Cellular Component Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Profilin Binding Developmental Process Regulation Of Organelle Organization Regulation Of Actin Nucleation Postsynaptic Density Vesicle Membrane Cell Projection Organization Positive Regulation Of Actin Nucleation Regulation Of Store-operated Calcium Entry	Positive Regulation Of Protein Localization To Centrosome Regulation Of Protein Localization To Centrosome Organelle Organization Regulation Of Macroautophagy Structural Constituent Of Skin Epidermis Intermediate Filament Organization Positive Regulation Of Response To Endoplasmic Reticulum Stress Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Anatomical Structure Morphogenesis Autophagosome Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Autophagosome Assembly Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Organelle Assembly Autophagosome Organization Regulation Of Organelle Organization Golgi Organization Regulation Of ERAD Pathway Positive Regulation Of Catabolic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Hair Follicle Morphogenesis Identical Protein Binding Positive Regulation Of ERBB Signaling Pathway Intra-Golgi Vesicle-mediated Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Depolymerization Regulation Of Protein Catabolic Process Regulation Of Protein Stability Regulation Of Autophagy Intermediate Filament Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Microtubule Polymerization Or Depolymerization Cytoskeleton Epithelial Cell Differentiation Structural Molecule Activity Vacuole Organization Negative Regulation Of Store-operated Calcium Channel Activity Tissue Morphogenesis Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Peptidyl-tyrosine Phosphorylation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of G Protein-coupled Receptor Internalization
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