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ZNF219 and CDK4
Number of citations of the paper that reports this interaction (PMID
22094256
)
37
Data Source:
BioGRID
(enzymatic study)
ZNF219
CDK4
Gene Name
zinc finger protein 219
cyclin-dependent kinase 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Integral Component Of Membrane
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytosol
Tight Junction
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Histamine Receptor Activity
Protein Binding
Metal Ion Binding
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Cyclin Binding
Protein Complex Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Neurotransmitter Levels
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Lens Development In Camera-type Eye
Chromatin Organization
Protein Phosphorylation
Signal Transduction
Circadian Rhythm
Positive Regulation Of Cell Proliferation
Response To Toxic Substance
Response To Lead Ion
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Organ Regeneration
Response To Testosterone
Response To Drug
Positive Regulation Of Apoptotic Process
Positive Regulation Of Translation
Positive Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Positive Regulation Of Fibroblast Proliferation
Cell Division
Response To Hyperoxia
Negative Regulation Of Cell Cycle Arrest
Pathways
Meiotic recombination
Chromatin organization
Ubiquitin-dependent degradation of Cyclin D
Cellular Senescence
G1 Phase
Senescence-Associated Secretory Phenotype (SASP)
S Phase
Oncogene Induced Senescence
Cell Cycle, Mitotic
Ubiquitin-dependent degradation of Cyclin D1
RMTs methylate histone arginines
Cyclin D associated events in G1
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
Transcriptional regulation of white adipocyte differentiation
Mitotic G1-G1/S phases
Drugs
Diseases
GWAS
Celiac disease and Rheumatoid arthritis (
21383967
)
Protein-Protein Interactions
11 interactors:
BCL2L1
CDK4
CSNK2A2
CTBP1
LMO1
MAPK3
MAPK8
SH3GL2
SH3KBP1
SUFU
TTC32
90 interactors:
ANKRD12
ANXA7
APLP1
APP
ARID4A
ATP5B
BAG6
BCL11A
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CDC37
CDC45
CDC6
CDC7
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
DAZAP2
DDAH2
DUSP9
FOXM1
GLI1
H1F0
HIST1H1A
HIST1H1D
HMGXB3
HOOK1
IFI27
IL15RA
LUC7L2
MAPRE2
MARCKS
MCM2
MYC
MYOD1
MZF1
NCOA2
NOL12
ORC3
OTX2
PGD
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
TGFBR1
TK1
TRMT2A
TSPYL2
UBTF
UHRF2
VTA1
WDR33
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
ZSCAN1
Entrez ID
51222
1019
HPRD ID
05435
00447
Ensembl ID
ENSG00000165804
ENSG00000135446
Uniprot IDs
Q9P2Y4
P11802
Q6LC83
PDB IDs
1LD2
2W96
2W99
2W9F
2W9Z
3G33
Enriched GO Terms of Interacting Partners
?
Regulation Of Chromosome Organization
Regulation Of Cellular Component Organization
Regulation Of Histone Modification
Regulation Of Organelle Organization
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Neurotrophin Signaling Pathway
Protein Phosphorylation
Regulation Of Histone Deacetylation
Endocytosis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Transduction
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Histone Acetylation
Regulation Of Protein Deacetylation
Negative Regulation Of Protein Binding
Regulation Of Metabolic Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Signaling
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cell Part Morphogenesis
TRIF-dependent Toll-like Receptor Signaling Pathway
Cell Communication
Regulation Of Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Cell Cycle
MyD88-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Mechanical Stimulus
Positive Regulation Of Histone Modification
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Apoptotic Process In Bone Marrow
Negative Regulation Of Apolipoprotein Binding
Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification
Negative Regulation Of Cellular Protein Catabolic Process
Cell Cycle
Regulation Of Cell Cycle
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cell Cycle Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Kinase Activity
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Gene Expression
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Mitotic Cell Cycle
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Phosphorylation
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Protein Kinase Activity
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Gene Expression
Regulation Of Cell Proliferation
Biosynthetic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cell Cycle
RNA Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Phosphorylation
Gene Expression
Negative Regulation Of Cell Cycle
Positive Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Negative Regulation Of Phosphorylation
Chromosome Organization
Regulation Of Nucleic Acid-templated Transcription
Transcription, DNA-templated
Regulation Of RNA Biosynthetic Process
Tagcloud
?
aberrantly
acetylglucosaminyltransferase
antigens
bage
ctl
ecto
fig
fm3
fm57
gage
gp100
immunogenic
immunogenicity
in4
maa
mage
mart
melan
melanocyte
melanomas
p15
pbl
permitted
pointing
prame
ref
tab
trp
tyrosinase
uncloned
Tagcloud (Difference)
?
aberrantly
acetylglucosaminyltransferase
antigens
bage
ctl
ecto
fig
fm3
fm57
gage
gp100
immunogenic
immunogenicity
in4
maa
mage
mart
melan
melanocyte
melanomas
p15
pbl
permitted
pointing
prame
ref
tab
trp
tyrosinase
uncloned
Tagcloud (Intersection)
?