ZNF219 and SUFU

Number of citations of the paper that reports this interaction (PMID 14611647)
23

Data Source:
HPRD (two hybrid)

		ZNF219	SUFU
Gene Name		zinc finger protein 219	suppressor of fused homolog (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Histamine Receptor Activity Protein Binding Metal Ion Binding	Transcription Corepressor Activity Signal Transducer Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neurotransmitter Levels Transcription, DNA-templated Regulation Of Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Neural Tube Closure Heart Looping Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organismal Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Negative Regulation Of Transcription Factor Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways			Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		11 interactors: BCL2L1 CDK4 CSNK2A2 CTBP1 LMO1 MAPK3 MAPK8 SH3GL2 SH3KBP1 SUFU TTC32	26 interactors: BTRC GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF747 ZNF764
Entrez ID		51222	51684
HPRD ID		05435	06124
Ensembl ID		ENSG00000165804	ENSG00000107882
Uniprot IDs		Q9P2Y4	Q9UMX1
PDB IDs			1M1L
Enriched GO Terms of Interacting Partners?		Regulation Of Chromosome Organization Regulation Of Cellular Component Organization Regulation Of Histone Modification Regulation Of Organelle Organization Apoptotic Process Programmed Cell Death Cell Death Death Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Protein Phosphorylation Regulation Of Histone Deacetylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Histone Acetylation Regulation Of Protein Deacetylation Negative Regulation Of Protein Binding Regulation Of Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signaling Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Part Morphogenesis TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Cycle MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Positive Regulation Of Histone Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process In Bone Marrow Negative Regulation Of Apolipoprotein Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Negative Regulation Of Cellular Protein Catabolic Process	RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Smoothened Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Notochord Regression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Mammary Gland Morphogenesis Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Tube Morphogenesis Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Ventral Midline Development Gland Development Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organ Formation Proximal/distal Pattern Formation Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Pituitary Gland Development Gland Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Mammary Gland Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Tagcloud ?			beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Difference) ?			beta1 blots cck colorectal constructed counting enhances gli1 hedgehog hh ht29 infecting integrin interference invasion itgb1 kit lentiviral lentivirus malignancies migrating rnai shh sonic transwell unrelated vectors xenografted xenografting
Tagcloud (Intersection) ?