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ZNF219 and BCL2L1
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
ZNF219
BCL2L1
Gene Name
zinc finger protein 219
BCL2-like 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Integral Component Of Membrane
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Centrosome
Cytosol
Integral Component Of Membrane
Cell Junction
Synaptic Vesicle Membrane
Nuclear Membrane
Bcl-2 Family Protein Complex
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Histamine Receptor Activity
Protein Binding
Metal Ion Binding
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
BH3 Domain Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Neurotransmitter Levels
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Cytokinesis
Ovarian Follicle Development
In Utero Embryonic Development
Release Of Cytochrome C From Mitochondria
Endocytosis
Apoptotic Process
Mitotic Cell Cycle Checkpoint
Germ Cell Development
Spermatogenesis
Cell Proliferation
Positive Regulation Of Cell Proliferation
Male Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Mitochondrial Changes
Fertilization
Negative Regulation Of Autophagy
Suppression By Virus Of Host Apoptotic Process
Response To Cytokine
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Growth
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Response To Cycloheximide
Regulation Of Mitochondrial Membrane Permeability
Neuron Apoptotic Process
Regulation Of Mitochondrial Membrane Potential
Cellular Process Regulating Host Cell Cycle In Response To Virus
Mitochondrion Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Alkaloid
Cellular Response To Gamma Radiation
Apoptotic Process In Bone Marrow
Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Hepatocyte Apoptotic Process
Negative Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Anoikis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Inflammasomes
The NLRP1 inflammasome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Programmed Cell Death
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Innate Immune System
Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
BCL2L1
CDK4
CSNK2A2
CTBP1
LMO1
MAPK3
MAPK8
SH3GL2
SH3KBP1
SUFU
TTC32
79 interactors:
ACTB
AKT1
ANTXR1
APAF1
AVEN
BAD
BAG1
BAK1
BAX
BBC3
BCAP31
BCL2
BCL2L10
BCL2L11
BCL2L12
BCL2L14
BCLAF1
BECN1
BID
BIK
BLK
BMF
BNIP1
BNIP3
BNIP3L
BNIPL
CAPN1
CASP1
CASP8
CASP9
CDKN2A
CFLAR
CRYAA
CRYAB
CYCS
DOCK7
EDRF1
FBP1
FKBP8
GLOD4
HRK
IKZF3
IRS1
IRS2
LARP1
MAPK8
MCL1
METTL23
MOAP1
MTOR
NLRP1
PARK7
PDIA4
PLD3
PMAIP1
PPHLN1
PPP1CA
PSEN1
PSEN2
PTN
RAD9A
RAF1
RBM5
RTN1
RTN4
SIVA1
SNCA
SPNS1
TLE1
TMBIM6
TP53
TP53BP2
TPT1
UBR1
UHRF2
VDAC1
ZFYVE1
ZHX1
ZNF219
Entrez ID
51222
598
HPRD ID
05435
02497
Ensembl ID
ENSG00000165804
ENSG00000171552
Uniprot IDs
Q9P2Y4
Q07817
Q5TE63
PDB IDs
1BXL
1G5J
1LXL
1MAZ
1R2D
1R2E
1R2G
1R2H
1R2I
1YSG
1YSI
1YSN
2B48
2LP8
2LPC
2M03
2M04
2O1Y
2O2M
2O2N
2P1L
2PON
2YJ1
2YQ6
2YQ7
2YXJ
3CVA
3FDL
3FDM
3INQ
3IO8
3PL7
3QKD
3R85
3SP7
3SPF
3ZK6
3ZLN
3ZLO
3ZLR
4A1U
4A1W
4AQ3
4EHR
4HNJ
4IEH
Enriched GO Terms of Interacting Partners
?
Regulation Of Chromosome Organization
Regulation Of Cellular Component Organization
Regulation Of Histone Modification
Regulation Of Organelle Organization
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Neurotrophin Signaling Pathway
Protein Phosphorylation
Regulation Of Histone Deacetylation
Endocytosis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Transduction
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Histone Acetylation
Regulation Of Protein Deacetylation
Negative Regulation Of Protein Binding
Regulation Of Metabolic Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Signaling
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cell Part Morphogenesis
TRIF-dependent Toll-like Receptor Signaling Pathway
Cell Communication
Regulation Of Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Cell Cycle
MyD88-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Mechanical Stimulus
Positive Regulation Of Histone Modification
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Apoptotic Process In Bone Marrow
Negative Regulation Of Apolipoprotein Binding
Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification
Negative Regulation Of Cellular Protein Catabolic Process
Apoptotic Process
Programmed Cell Death
Regulation Of Apoptotic Process
Cell Death
Death
Regulation Of Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrion Organization
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Mitochondrion Organization
Regulation Of Cysteine-type Endopeptidase Activity
Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Mitochondrial Changes
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endopeptidase Activity
Zymogen Activation
Positive Regulation Of Peptidase Activity
Regulation Of Endopeptidase Activity
Negative Regulation Of Programmed Cell Death
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Peptidase Activity
Negative Regulation Of Cell Death
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Protein Processing
Positive Regulation Of Proteolysis
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitochondrial Membrane Permeability
Regulation Of Membrane Permeability
Regulation Of Proteolysis
Mitochondrial Membrane Organization
Positive Regulation Of Organelle Organization
Positive Regulation Of Protein Oligomerization
Regulation Of Cellular Process
Regulation Of Intracellular Transport
Mitochondrion Organization
Tagcloud
?
aacr
antiapoptotic
antiestrogens
aromatase
competitive
deprivation
drives
escaped
estrogen
eventually
fulvestrant
hcc1428
junb
kinome
letrozole
lted
mcf7
ovariectomized
parental
pharmacologic
plk1
polo
potently
recur
res
rnai
top
volasertib
xl
Tagcloud (Difference)
?
aacr
antiapoptotic
antiestrogens
aromatase
competitive
deprivation
drives
escaped
estrogen
eventually
fulvestrant
hcc1428
junb
kinome
letrozole
lted
mcf7
ovariectomized
parental
pharmacologic
plk1
polo
potently
recur
res
rnai
top
volasertib
xl
Tagcloud (Intersection)
?