ZNF219 and UFL1

Number of citations of the paper that reports this interaction (PubMedID 32545848)
54

Data Source:
BioGRID (two hybrid)

		ZNF219	UFL1
Description		zinc finger protein 219	UFM1 specific ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Nucleus Chromosome Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex Site Of Double-strand Break Neuron Projection
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histamine Receptor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Transferase Activity Protein Kinase Binding UFM1 Ligase Activity UFM1 Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Limb Bud Formation	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Osteoblast Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Repair DNA Damage Response Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Autophagy Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Protein Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Hematopoietic Stem Cell Differentiation Positive Regulation Of Glial Cell Proliferation Reticulophagy Protein Ufmylation Rescue Of Stalled Ribosome Antiviral Innate Immune Response Positive Regulation Of Reticulophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Response To L-glutamate Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein K69-linked Ufmylation
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Resting heart rate ( 27798624)	Diastolic blood pressure ( 27841878) Headache ( 29397368) Language functional connectivity ( 34929384) Migraine ( 27322543) Migraine without aura ( 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Walking pace ( 33128006)
Interacting Genes		17 interacting genes: AP1M1 ATOSB BCL2L1 CDK4 CSNK2A2 CTBP1 GRIPAP1 LMO1 MAPK3 MAPK8 SH3GL2 SH3KBP1 SUFU TRIM41 TTC32 UBASH3A UFL1	17 interacting genes: AHCY AKAP17A ATP4A ENY2 FGB H2AC4 HINFP IRAK1BP1 IRF3 MT1M PPIL1 PTPRO TIPRL TP53 TSC22D3 UFC1 ZNF219
Entrez ID		51222	23376
HPRD ID		05435	11109
Ensembl ID		ENSG00000165804	ENSG00000014123
Uniprot IDs		Q9P2Y4	O94874
PDB IDs			8B9X 8C0D 8OHD 8OJ0 8OJ5 8OJ8 8QFC 8QFD
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Glutamatergic Synapse Endocytosis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell MAP Kinase Activity Synapse Regulation Of Protein Localization Response To Lipopolysaccharide Positive Regulation Of Cyclase Activity Stress-activated MAPK Cascade NLRP3 Inflammasome Complex Assembly Negative Regulation Of Signal Transduction Import Into Cell Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cytosol Response To Molecule Of Bacterial Origin Protein Serine Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Response To Tumor Cell Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Catabolic Process Regulation Of Proteolysis Canonical Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of T Cell Mediated Immunity Regulation Of Immune System Process Cellular Response To Lipopolysaccharide Synaptic Vesicle Endocytosis Vesicle-mediated Transport DNA Damage Response Negative Regulation Of Metabolic Process Apoptotic Process In Bone Marrow Cell Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Presynaptic Endocytosis DNA-binding Transcription Factor Binding JUN Phosphorylation UFM1 Ligase Activity Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Extrinsic Component Of Postsynaptic Early Endosome Membrane
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