ZNF219 and TRIM41

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF219	TRIM41
Description		zinc finger protein 219	tripartite motif containing 41
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histamine Receptor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Limb Bud Formation	Protein Monoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Innate Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Resting heart rate ( 27798624)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: AP1M1 ATOSB BCL2L1 CDK4 CSNK2A2 CTBP1 GRIPAP1 LMO1 MAPK3 MAPK8 SH3GL2 SH3KBP1 SUFU TRIM41 TTC32 UBASH3A UFL1	144 interacting genes: AEN AKTIP ANKRD23 AP1M1 APP AQP1 BIVM BRAP BYSL C8orf33 CARD10 CCNL2 CEP44 CHD2 CSNK2A1 CSNK2A2 DDX41 DEPTOR DRC4 DVL3 EHHADH EZHIP FAM124A FAM161A FAM9A FLACC1 FRA10AC1 GPATCH2L IKBKG JRK KATNBL1 KIFC3 KRTAP10-8 KRTAP10-9 MAGEH1 MCRS1 MEOX1 MEOX2 MFAP1 MID2 MOBP MORF4L1 MORF4L2 MPP3 NCK2 NEDD4L NFE2L2 NOD2 PBX4 PHC2 PHF11 PHF7 PLAGL2 PRDM14 PRKCA PRKCB PRPF31 PTPN3 PUS7L RBAK RNPS1 SORBS3 SRPK2 STX11 SUV39H1 SYCE1 SYTL4 TBC1D26 TCEA2 TCEANC TLE5 TNNI1 TOP3B TP53 TRAIP TRIM17 TRIM26 TRIM4 TRIM52 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2I ZBTB24 ZBTB26 ZBTB38 ZBTB39 ZBTB48 ZBTB8A ZCCHC7 ZFP1 ZFP2 ZFP64 ZMAT5 ZNF121 ZNF134 ZNF138 ZNF165 ZNF2 ZNF219 ZNF24 ZNF250 ZNF251 ZNF26 ZNF263 ZNF264 ZNF266 ZNF275 ZNF286A ZNF319 ZNF329 ZNF343 ZNF398 ZNF408 ZNF417 ZNF439 ZNF460 ZNF473 ZNF48 ZNF490 ZNF497 ZNF526 ZNF552 ZNF564 ZNF575 ZNF587 ZNF629 ZNF648 ZNF653 ZNF655 ZNF670 ZNF691 ZNF696 ZNF71 ZNF773 ZNF780A ZNF784 ZNF792 ZNF835 ZNF837 ZSCAN16 ZSCAN21 ZSCAN26
Entrez ID		51222	90933
HPRD ID		05435	15558
Ensembl ID		ENSG00000165804	ENSG00000146063
Uniprot IDs		Q9P2Y4	Q8WV44
PDB IDs			2EGM
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Glutamatergic Synapse Endocytosis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell MAP Kinase Activity Synapse Regulation Of Protein Localization Response To Lipopolysaccharide Positive Regulation Of Cyclase Activity Stress-activated MAPK Cascade NLRP3 Inflammasome Complex Assembly Negative Regulation Of Signal Transduction Import Into Cell Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cytosol Response To Molecule Of Bacterial Origin Protein Serine Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Response To Tumor Cell Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Catabolic Process Regulation Of Proteolysis Canonical Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of T Cell Mediated Immunity Regulation Of Immune System Process Cellular Response To Lipopolysaccharide Synaptic Vesicle Endocytosis Vesicle-mediated Transport DNA Damage Response Negative Regulation Of Metabolic Process Apoptotic Process In Bone Marrow Cell Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Presynaptic Endocytosis DNA-binding Transcription Factor Binding JUN Phosphorylation UFM1 Ligase Activity Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Extrinsic Component Of Postsynaptic Early Endosome Membrane	Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Metal Ion Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Negative Regulation Of DNA-templated Transcription Histone H3T6 Kinase Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Kinase CK2 Complex Protein Ubiquitination Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Protein Kinase C Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Stem Cell Differentiation Somite Specification
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