PLEKHO1 and CDC42SE1

Data Source: HiPPIP (Novel)

		PLEKHO1	CDC42SE1
Name		pleckstrin homology domain containing O1	CDC42 small effector 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane	Cytoplasm Cytoskeleton Plasma Membrane Membrane Cell Junction
	Molecular Function	Protein Binding	GTPase Inhibitor Activity Protein Binding Small GTPase Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion	Phagocytosis Signal Transduction Regulation Of Cell Shape Regulation Of Rho Protein Signal Transduction
GWAS		Bipolar disorder ( 31043756 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )	No GWAS studies recorded
Novel Interactors		7 novel interactors: ADAMTSL4 C1orf56 CDC42SE1 GOLPH3L RPRD2 SMG5 SYT11	3 novel interactors: OTUD7B PLEKHO1 SLC44A2
Interacting Genes		33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	4 interacting genes: CDC42 DAPK1 RAC1 SNCA
Entrez ID		51177	56882
HPRD ID		12217	16694
Ensembl ID		ENSG00000023902	ENSG00000197622
Uniprot IDs		Q53GL0 Q5T4P9	Q9NRR8
PDB IDs		3AA1	Not available
GO Terms Enriched among Interactors		Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response	Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Response To Type II Interferon Regulation Of Hydrogen Peroxide Metabolic Process GTP-dependent Protein Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Phagocytosis, Engulfment Postsynapse Regulation Of Synaptic Vesicle Recycling Cell Projection Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Invagination Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Endocytosis Lamellipodium Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Neuronal Synaptic Plasticity Regulation Of Cell Communication GTP Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Signaling Regulation Of Supramolecular Fiber Organization Cellular Response To Type II Interferon Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Microtubule Polymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cytoplasmic Ribonucleoprotein Granule Regulation Of Protein-containing Complex Assembly Positive Regulation Of Intracellular Signal Transduction Endocytosis Regulation Of Stress Fiber Assembly GBD Domain Binding Storage Vacuole Positive Regulation Of Organelle Organization Cell Junction Organization