PLEKHO1 and RPRD2

		PLEKHO1	RPRD2
Description		pleckstrin homology domain containing O1	regulation of nuclear pre-mRNA domain containing 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane	Nucleoplasm Transcription Preinitiation Complex
	Molecular Function	Protein Binding	RNA Polymerase II Complex Binding RNA Polymerase II C-terminal Domain Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion	MRNA 3'-end Processing
Pathways			RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Bitter non-alcoholic beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Broad depression or bipolar disorder ( 30626913) Caffeine consumption from tea ( 33287642) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Lung function (FEV1) ( 30175238) Neutrophil count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256) Spontaneous coronary artery dissection ( 32887874) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	7 interacting genes: CSNK2A1 CTDSP1 MTNR1B PPP1CA PPP1CC SPOP UPF1
Entrez ID		51177	23248
HPRD ID		12217	11084
Ensembl ID		ENSG00000023902	ENSG00000163125
Uniprot IDs		Q53GL0 Q5T4P9	Q5VT52
PDB IDs		3AA1	4FLB
Enriched GO Terms of Interacting Partners?		Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response	Protein Dephosphorylation Phosphatase Activity PTW/PP1 Phosphatase Complex Protein Serine/threonine Phosphatase Activity Regulation Of Circadian Rhythm Dephosphorylation Phosphoprotein Phosphatase Activity Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Chromosome, Telomeric Region Rhythmic Process Double-strand Break Repair Via Nonhomologous End Joining Glycogen Metabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Protein-containing Complex Binding Chromosome Organization Polysaccharide Metabolic Process Regulation Of Translation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body DNA Repair Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Telomere Maintenance Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Regulation Of Protein-containing Complex Disassembly Telomere Organization Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Double-stranded DNA Helicase Activity Supraspliceosomal Complex Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Muscle Cell Projection Membrane Positive Regulation Of Aggrephagy Regulation Of Neuronal Action Potential Dendritic Spine Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Transmission Of Nerve Impulse Glycogen Granule Positive Regulation Of Transmission Of Nerve Impulse
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