PLEKHO1 and SMG5

Data Source: HiPPIP (Novel)

		PLEKHO1	SMG5
Name		pleckstrin homology domain containing O1	SMG5 nonsense mediated mRNA decay factor
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation
Pathways		None	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GWAS		Bipolar disorder ( 31043756 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )	Glycated hemoglobin levels ( 29170429 ) Hemoglobin A1c levels ( 29403010 ) Mean corpuscular hemoglobin concentration ( 20139978 29403010 )
Novel Interactors		7 novel interactors: ADAMTSL4 C1orf56 CDC42SE1 GOLPH3L RPRD2 SMG5 SYT11	2 novel interactors: CKB PLEKHO1
Interacting Genes		33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	8 interacting genes: APP BTG3 SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		51177	23381
HPRD ID		12217	16869
Ensembl ID		ENSG00000023902	ENSG00000198952
Uniprot IDs		Q53GL0 Q5T4P9	Q9UPR3
PDB IDs		3AA1	2HWY
GO Terms Enriched among Interactors		Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response	Telomeric DNA Binding Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus RNA Export From Nucleus Nuclear Transport Nucleocytoplasmic Transport Telomerase RNA Binding Telomerase Holoenzyme Complex Nuclear-transcribed MRNA Catabolic Process Nuclear Export MRNA Transport MRNA Catabolic Process RNA Transport RNA Catabolic Process Nucleobase-containing Compound Transport Intracellular Transport Protein-folding Chaperone Binding Regulation Of Telomere Maintenance Nucleobase-containing Compound Catabolic Process Exon-exon Junction Complex Cellular Localization Establishment Of Localization In Cell Regulation Of Dephosphorylation Chromosome, Telomeric Region Cytoplasm Macromolecule Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Response To Endoplasmic Reticulum Stress MRNA Metabolic Process Regulation Of Chromosome Organization Nucleic Acid Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA Metabolic Process TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Positive Regulation Of Chaperone-mediated Protein Complex Assembly RNA Metabolic Process G Protein-coupled Receptor Binding Regulation Of MiRNA Transcription Nucleus Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Response To Interleukin-1