SHANK1 and ABCA1

Number of citations of the paper that reports this interaction (PubMedID 16192279)
0

Data Source:
HPRD (in vitro)

		SHANK1	ABCA1
Description		SH3 and multiple ankyrin repeat domains 1	ATP binding cassette subfamily A member 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Intracellular Vesicle
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding SH3 Domain Binding Signaling Receptor Complex Adaptor Activity Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Density	Nucleotide Binding Signaling Receptor Binding Protein Binding ATP Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Protein Transmembrane Transporter Activity Cholesterol Binding ATP Hydrolysis Activity Syntaxin Binding Phosphatidylcholine Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase-coupled Transmembrane Transporter Activity Sphingolipid Floppase Activity ATPase Binding Phosphatidylcholine Floppase Activity Phosphatidylserine Floppase Activity Cholesterol Transfer Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Nervous System Development Long-term Memory Associative Learning Cell Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Cognition Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior AMPA Selective Glutamate Receptor Signaling Pathway Maintenance Of Postsynaptic Density Structure Positive Regulation Of Excitatory Postsynaptic Potential	Peptide Secretion Lipid Metabolic Process Phagocytosis, Engulfment Lysosome Organization G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process Cholesterol Metabolic Process Protein Secretion Response To Xenobiotic Stimulus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Organic Hydroxy Compound Transport Phospholipid Transport Endosomal Transport Signal Release Cholesterol Transport Response To Nutrient Levels Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Response To Vitamin B3 Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Phospholipid Translocation Establishment Of Localization In Cell Transmembrane Transport Phospholipid Homeostasis Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cytokine Stimulus Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Xenobiotic Stimulus Protein Transmembrane Transport Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Export Across Plasma Membrane
Pathways		Neurexins and neuroligins Neurexins and neuroligins	PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			ATP Glyburide Probucol
Diseases			Tangier disease Hypoalphalipoproteinemia
GWAS		Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Allergic rhinitis ( 25085501) Aluminium levels ( 26025379) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Cardiometabolic and hematological traits ( 27668658) Cholesterol, total ( 20686565 24097068 25961943 26582766) Coronary artery disease ( 29212778 33020668) Glaucoma ( 30054594 31959993) Glaucoma (high intraocular pressure) ( 25173107) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 25173105 29452408 29891935 33627673) Gout ( 22179738) HDL cholesterol ( 18193043 18193044 19060906 19060911 20686565 20864672 21347282 21909109 23505323 24097068 25961943 26160806 26582766 26780889 28270201 30275531) HDL cholesterol levels ( 26690388 28334899 30698716 31087446 31694877 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010 29615537 30718733 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 25173106 28073927 29235454 29617998 29785010 30054594 30591961 31798171 31959993) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Low high density lipoprotein cholesterol levels ( 26879886) Lung cancer in ever smokers ( 28604730) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolite levels ( 22916037 31628463) Myopia (pathological) ( 23049088) Pelvic organ prolapse ( 26545240) Periodontitis (Mean PAL) ( 24024966) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (total cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic mastocytosis ( 32752121) Total cholesterol levels ( 28334899 29403010 30275531 31087446 33339817) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		23 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 PRMT2 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8	41 interacting genes: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBIN FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ PALS2 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2
Entrez ID		50944	19
HPRD ID		05413	02501
Ensembl ID		ENSG00000161681	ENSG00000165029
Uniprot IDs		H9KV90 Q9Y566	B2RUU2 B7XCW9 O95477
PDB IDs		6CPI 6YWZ 6YX0 6YX1 6YX2 7A00 8S1R	5XJY 7ROQ 7TBW 7TBY 7TBZ 7TC0 7TDT
Enriched GO Terms of Interacting Partners?		Synapse Postsynaptic Density Neuron Projection Regulation Of Cellular Component Organization Neuron Spine Glutamatergic Synapse Signal Transduction Dendritic Spine Latrotoxin Receptor Activity Cell Projection Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Postsynapse AMPA Glutamate Receptor Clustering Neuron Projection Organization Ribosomal Protein S6 Kinase Activity Postsynapse Organization Regulation Of Postsynapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Synapse Organization Chemical Synaptic Transmission Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling TORC1 Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Plasma Membrane Scaffold Protein Binding Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Positive Regulation Of Signal Transduction Neurotransmitter-gated Ion Channel Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Axon Regulation Of Signal Transduction PDZ Domain Binding Costamere Cytosol TOR Signaling Regulation Of Biological Quality Positive Regulation Of Developmental Process Postsynaptic Membrane	Anchoring Junction MPP7-DLG1-LIN7 Complex Synapse Plasma Membrane Neuromuscular Junction PDZ Domain Binding Regulation Of Synaptic Assembly At Neuromuscular Junction Neurotransmitter Secretion Postsynaptic Density Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Dystrophin-associated Glycoprotein Complex Cell-cell Junction Intracellular Protein Localization Bicellular Tight Junction Protein Kinase CK2 Complex L27 Domain Binding Protein-containing Complex Organization Basolateral Plasma Membrane Cellular Component Assembly Protein-containing Complex Assembly Establishment Or Maintenance Of Cell Polarity Signal Release Protein Localization To Cell Junction Ionotropic Glutamate Receptor Binding Synaptic Vesicle Transport Adherens Junction Neurotransmitter Transport Regulation Of Macroautophagy Establishment Of Vesicle Localization Neuron Projection Vesicle Localization Membrane High-density Lipoprotein Particle Assembly Postsynaptic Membrane Regulation Of Autophagy High-density Lipoprotein Particle Binding Cytoplasm Protein Localization To Synapse Postsynaptic Density Glutamatergic Synapse Regulation Of Monoatomic Anion Transport Small GTPase-mediated Signal Transduction Regulation Of Cell Junction Assembly Rho Protein Signal Transduction Muscle Alpha-actinin Binding Apical Protein Localization Regulation Of Cellular Component Organization Regulation Of Growth Cytoskeletal Protein Binding
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