ABCA1 and MPP6

Number of citations of the paper that reports this interaction (PMID 16192290)
8

Data Source:
HPRD (in vitro)

		ABCA1	MPP6
Gene Name		ATP-binding cassette, sub-family A (ABC1), member 1	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle High-density Lipoprotein Particle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding ATP Binding Phospholipid Binding Phospholipid Transporter Activity Anion Transmembrane Transporter Activity Cholesterol Binding ATPase Activity Cholesterol Transporter Activity Syntaxin Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Binding	Protein Binding PDZ Domain Binding
	Biological Process	Peptide Secretion Protein Lipidation Phagocytosis, Engulfment Lysosome Organization G-protein Coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Positive Regulation Of CAMP Biosynthetic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Phospholipid Translocation Interleukin-1 Beta Secretion Phospholipid Homeostasis Response To Low-density Lipoprotein Particle Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol	Protein Complex Assembly
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport
Drugs		Adenosine triphosphate Glyburide Probucol
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 21909109 18193043 18193044 20864672 19060906 23505323 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) MRI atrophy measures ( 21116278) Myopia (pathological) ( 23049088)
Protein-Protein Interactions		42 interactors: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBB2IP FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2 XPC	28 interactors: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 NDN NFKB1 PARN RPS20 SKIV2L2 SMARCA4 SNX9 THOP1
Entrez ID		19	51678
HPRD ID		02501	09509
Ensembl ID		ENSG00000165029	ENSG00000105926
Uniprot IDs		B2RUU2 B7XCW9 O95477	B8ZZG1 Q9NZW5
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Chemotaxis Neuron Projection Development Maintenance Of Cell Polarity Cell Projection Organization Protein Localization To Membrane Neuron Development Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Synapse Protein Localization To Plasma Membrane Cellular Component Assembly Protein Localization Cellular Protein Localization Neuron Projection Morphogenesis Nervous System Development Neuron Differentiation Regulation Of Catalytic Activity Signaling Cellular Localization Cell Morphogenesis Involved In Differentiation Cell Communication Axonogenesis Cell Development Response To External Stimulus Anatomical Structure Development Locomotion Plasma Membrane Organization Neurotransmitter Secretion Protein Complex Assembly System Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Endomembrane System Organization Regulation Of Neurotransmitter Levels Cell-cell Signaling Receptor Localization To Synapse Movement Of Cell Or Subcellular Component Developmental Process Apoptotic Process Generation Of Neurons Neurotransmitter Transport	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis RRNA Processing RRNA Metabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance NcRNA Metabolic Process RNA Surveillance RRNA Catabolic Process Cellular Macromolecule Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Maturation Of 5.8S RRNA Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Gene Expression RNA Metabolic Process DNA Deamination Catabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Growth Histone MRNA Catabolic Process Regulation Of Growth Intracellular MRNA Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-lipid Complex Assembly Histone MRNA Metabolic Process Membrane Organization Positive Regulation Of Cell Growth Cellular Process RNA Processing Cellular Metabolic Process Regulation Of Cholesterol Transport Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Interleukin-12 Biosynthetic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover
Tagcloud (Difference) ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	binds cofactor cofactors composite conserved core create crystallographic disrupts exo exoribonuclease exosome functionally gfp groove helicase insight interface intertwined mtr4 physically revealing ribonuclease rnas rrp47 rrp6 structural synergize turnover
Tagcloud (Intersection) ?