SHANK1 and DLG4

Number of citations of the paper that reports this interaction (PMID 10433268)
134

Data Source:
HPRD (in vivo, in vitro)

		SHANK1	DLG4
Gene Name		SH3 and multiple ankyrin repeat domains 1	discs, large homolog 4 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Cytoplasm Endoplasmic Reticulum Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Cytoplasm Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Somatostatin Receptor Binding Protein Complex Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Ankyrin Repeat Binding Scaffold Protein Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Protein Complex Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Protein Complex Assembly Cytoskeletal Anchoring At Plasma Membrane Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Neuromuscular Process Controlling Balance Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Negative Regulation Of Receptor Internalization Protein Complex Assembly Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Nervous System Development Axon Guidance Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Vocalization Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways			Axon guidance L1CAM interactions Activation of Kainate Receptors upon glutamate binding CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII NrCAM interactions Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Activation of Ca-permeable Kainate Receptor Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		17 interactors: ABCA1 ARHGEF7 BAI2 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 LPHN1 LPHN2 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1	104 interactors: ACTN2 ADRB1 AKAP5 ARHGAP32 ASIC3 ATP2B2 ATP2B4 BAI1 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRIPT DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB2IP ERBB4 EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRASP GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LPHN1 LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TANC1 WNT3A YES1 ZDHHC17
Entrez ID		50944	1742
HPRD ID		05413	04199
Ensembl ID		ENSG00000161681	ENSG00000132535
Uniprot IDs		H9KV90 Q9Y566	B7Z647 B9EGL1 P78352
PDB IDs			1KEF 3I4W 3K82 3ZRT
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Neuron Projection Morphogenesis Cell Projection Organization Signaling Nervous System Development Cell Communication Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Response To External Stimulus Anatomical Structure Development Cell-cell Signaling Axon Development Regulation Of Cellular Component Organization System Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Cell Differentiation Signal Transduction Cell Morphogenesis Developmental Process Axon Guidance Neuron Differentiation Cell Morphogenesis Involved In Differentiation Response To Stimulus Multicellular Organismal Development Cell Development Apoptotic Process Cellular Response To Stimulus Programmed Cell Death Chemotaxis Generation Of Neurons Cell Death Death Protein Localization To Synapse Neurogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Organization G-protein Coupled Receptor Signaling Pathway Anatomical Structure Morphogenesis Response To Organic Substance Cellular Response To Organic Substance Regulation Of Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Response To Bacterium Neurotrophin TRK Receptor Signaling Pathway Response To Nutrient Neurotrophin Signaling Pathway	Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Membrane Depolarization Nervous System Development Regulation Of Postsynaptic Membrane Potential Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Neurological System Process Neuron-neuron Synaptic Transmission Glutamate Receptor Signaling Pathway Signal Transduction Metal Ion Transport Synaptic Transmission, Glutamatergic Neurogenesis Response To Stimulus Ion Transport Generation Of Neurons Cellular Response To Stimulus Transport System Development Cation Transport Cell Surface Receptor Signaling Pathway Single-organism Behavior Sensory Perception Of Pain Behavior Neuron Differentiation Regulation Of Signal Transduction Response To Abiotic Stimulus Ion Transmembrane Transport Regulation Of Cellular Localization Anatomical Structure Development Regulation Of Cellular Process Membrane Hyperpolarization Cell Differentiation Cation Transmembrane Transport Multicellular Organismal Development Developmental Process Regulation Of Phosphorus Metabolic Process Learning Response To External Stimulus Cellular Process Neuron Development Positive Regulation Of Signal Transduction
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 sumo1 sypl1 tkt topbp1 znf668	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 sumo1 sypl1 tkt topbp1 znf668	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Intersection) ?