SHANK1 and LPHN2

Number of citations of the paper that reports this interaction (PMID 10964907)
14

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHANK1	LPHN2
Gene Name		SH3 and multiple ankyrin repeat domains 1	latrophilin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Somatostatin Receptor Binding Protein Complex Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Ankyrin Repeat Binding Scaffold Protein Binding	G-protein Coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding
	Biological Process	Protein Complex Assembly Cytoskeletal Anchoring At Plasma Membrane Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Neuromuscular Process Controlling Balance Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential	G-protein Coupled Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Temperament ( 22832960)
Protein-Protein Interactions		17 interactors: ABCA1 ARHGEF7 BAI2 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 LPHN1 LPHN2 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1	3 interactors: NCK1 SHANK1 SHANK2
Entrez ID		50944	23266
HPRD ID		05413	06116
Ensembl ID		ENSG00000161681	ENSG00000117114
Uniprot IDs		H9KV90 Q9Y566	O95490
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Neuron Projection Morphogenesis Cell Projection Organization Signaling Nervous System Development Cell Communication Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Response To External Stimulus Anatomical Structure Development Cell-cell Signaling Axon Development Regulation Of Cellular Component Organization System Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Cell Differentiation Signal Transduction Cell Morphogenesis Developmental Process Axon Guidance Neuron Differentiation Cell Morphogenesis Involved In Differentiation Response To Stimulus Multicellular Organismal Development Cell Development Apoptotic Process Cellular Response To Stimulus Programmed Cell Death Chemotaxis Generation Of Neurons Cell Death Death Protein Localization To Synapse Neurogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Organization G-protein Coupled Receptor Signaling Pathway Anatomical Structure Morphogenesis Response To Organic Substance Cellular Response To Organic Substance Regulation Of Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Response To Bacterium Neurotrophin TRK Receptor Signaling Pathway Response To Nutrient Neurotrophin Signaling Pathway	Vocalization Behavior Social Behavior Memory Learning Determination Of Affect Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Adult Behavior Synapse Organization Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Peptidyl-serine Dephosphorylation Habituation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Sensory Processing Learning Or Memory Cognition Cellular Component Assembly Nonassociative Learning Regulation Of Actin Cytoskeleton Organization Righting Reflex Synapse Maturation Regulation Of Actin Filament-based Process Nervous System Development Olfactory Behavior Single-organism Behavior Substrate-dependent Cell Migration, Cell Extension Regulation Of Cytoplasmic Translation Regulation Of Cytoskeleton Organization Cytoskeletal Anchoring At Plasma Membrane Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Dendritic Spine Morphogenesis Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Translational Initiation Signal Complex Assembly Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemosensory Behavior Regulation Of Translation In Response To Stress Long Term Synaptic Depression Neuron Projection Morphogenesis Dendritic Spine Development Regulation Of Signaling Protein Localization To Synapse Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Reflex Dendritic Spine Organization Cell Morphogenesis Involved In Differentiation
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 sumo1 sypl1 tkt topbp1 znf668	arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 missense pard6b pde4c pias2 proline prpf40a pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 sumo1 sypl1 tkt topbp1 znf668	arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 missense pard6b pde4c pias2 proline prpf40a pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic
Tagcloud (Intersection) ?