ABCA1 and SNTB2

Number of citations of the paper that reports this interaction (PMID 12054535)
6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		ABCA1	SNTB2
Gene Name		ATP-binding cassette, sub-family A (ABC1), member 1	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle High-density Lipoprotein Particle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Microtubule Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Transport Vesicle Membrane Protein Complex Synapse Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding ATP Binding Phospholipid Binding Phospholipid Transporter Activity Anion Transmembrane Transporter Activity Cholesterol Binding ATPase Activity Cholesterol Transporter Activity Syntaxin Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Binding	Actin Binding Protein Binding Calmodulin Binding Poly(A) RNA Binding
	Biological Process	Peptide Secretion Protein Lipidation Phagocytosis, Engulfment Lysosome Organization G-protein Coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Positive Regulation Of CAMP Biosynthetic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Phospholipid Translocation Interleukin-1 Beta Secretion Phospholipid Homeostasis Response To Low-density Lipoprotein Particle Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport
Drugs		Adenosine triphosphate Glyburide Probucol
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 21909109 18193043 18193044 20864672 19060906 23505323 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) MRI atrophy measures ( 21116278) Myopia (pathological) ( 23049088)
Protein-Protein Interactions		42 interactors: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBB2IP FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2 XPC	15 interactors: ABCA1 ADRA1D BAI1 DGKZ DMD DTNA ERBB4 KCNJ12 MAST1 MAST2 PTPRN SCN4A SCN5A UBC UTRN
Entrez ID		19	6645
HPRD ID		02501	02491
Ensembl ID		ENSG00000165029	ENSG00000168807
Uniprot IDs		B2RUU2 B7XCW9 O95477	Q13425
PDB IDs			2VRF
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Chemotaxis Neuron Projection Development Maintenance Of Cell Polarity Cell Projection Organization Protein Localization To Membrane Neuron Development Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Synapse Protein Localization To Plasma Membrane Cellular Component Assembly Protein Localization Cellular Protein Localization Neuron Projection Morphogenesis Nervous System Development Neuron Differentiation Regulation Of Catalytic Activity Signaling Cellular Localization Cell Morphogenesis Involved In Differentiation Cell Communication Axonogenesis Cell Development Response To External Stimulus Anatomical Structure Development Locomotion Plasma Membrane Organization Neurotransmitter Secretion Protein Complex Assembly System Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Endomembrane System Organization Regulation Of Neurotransmitter Levels Cell-cell Signaling Receptor Localization To Synapse Movement Of Cell Or Subcellular Component Developmental Process Apoptotic Process Generation Of Neurons Neurotransmitter Transport	Muscle Contraction Muscle System Process Signaling Cell Communication Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Cell-cell Signaling Action Potential Striated Muscle Contraction Regulation Of Ion Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transmembrane Transporter Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Positive Regulation Of Sodium Ion Transport Signal Transduction Cellular Response To Stimulus Cardiac Muscle Contraction Positive Regulation Of Cell-matrix Adhesion Regulation Of Membrane Potential Transmission Of Nerve Impulse Cardiac Muscle Tissue Regeneration Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Heart Contraction Peptide Secretion Blood Circulation Positive Regulation Of Transport Ion Transmembrane Transport Mitotic G1 DNA Damage Checkpoint Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Striated Muscle Contraction Central Nervous System Morphogenesis Establishment Of Glial Blood-brain Barrier Dense Core Granule Maturation Cell Projection Morphogenesis Cell Surface Receptor Signaling Pathway Peptide Transport Movement Of Cell Or Subcellular Component Mitotic DNA Damage Checkpoint Cell Part Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Positive Regulation Of STAT Protein Import Into Nucleus Negative Regulation Of Peptidyl-cysteine S-nitrosylation
Tagcloud ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	adp cleaved clonogenic concomitantly degs discovering ebp elucidating exhibiting fractionated grp78 h1299 h2ax h460 h460r helpful ionizing ir metalloproteinase organelles overcome parental radioresistance radioresistant ribose scattering syntrophin vesicular zymography
Tagcloud (Difference) ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	adp cleaved clonogenic concomitantly degs discovering ebp elucidating exhibiting fractionated grp78 h1299 h2ax h460 h460r helpful ionizing ir metalloproteinase organelles overcome parental radioresistance radioresistant ribose scattering syntrophin vesicular zymography
Tagcloud (Intersection) ?