ABCA1 and UGP2

Number of citations of the paper that reports this interaction (PMID 12054535)
6

Data Source:
HPRD (two hybrid)

		ABCA1	UGP2
Gene Name		ATP-binding cassette, sub-family A (ABC1), member 1	UDP-glucose pyrophosphorylase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle High-density Lipoprotein Particle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding ATP Binding Phospholipid Binding Phospholipid Transporter Activity Anion Transmembrane Transporter Activity Cholesterol Binding ATPase Activity Cholesterol Transporter Activity Syntaxin Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Binding	UTP:glucose-1-phosphate Uridylyltransferase Activity Protein Binding Glucose Binding Pyrimidine Ribonucleotide Binding Metal Ion Binding
	Biological Process	Peptide Secretion Protein Lipidation Phagocytosis, Engulfment Lysosome Organization G-protein Coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Positive Regulation Of CAMP Biosynthetic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Phospholipid Translocation Interleukin-1 Beta Secretion Phospholipid Homeostasis Response To Low-density Lipoprotein Particle Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process UDP-glucose Metabolic Process UDP-glucuronate Biosynthetic Process Xenobiotic Metabolic Process Pathogenesis Glucose 1-phosphate Metabolic Process Small Molecule Metabolic Process Cellular Glucuronidation
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Formation of the active cofactor, UDP-glucuronate Metabolic disorders of biological oxidation enzymes Glucose metabolism Phase II conjugation Glycogen synthesis Myoclonic epilepsy of Lafora Defective UGT1A1 causes hyperbilirubinemia Glycogen storage diseases Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Metabolism of carbohydrates Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Adenosine triphosphate Glyburide Probucol
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 21909109 18193043 18193044 20864672 19060906 23505323 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) MRI atrophy measures ( 21116278) Myopia (pathological) ( 23049088)
Protein-Protein Interactions		42 interactors: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBB2IP FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2 XPC	5 interactors: ABCA1 ARIH2 CBS GLRX3 PCBP1
Entrez ID		19	7360
HPRD ID		02501	08934
Ensembl ID		ENSG00000165029	ENSG00000169764
Uniprot IDs		B2RUU2 B7XCW9 O95477	E7EUC7 Q16851
PDB IDs			3R2W 3R3I
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Chemotaxis Neuron Projection Development Maintenance Of Cell Polarity Cell Projection Organization Protein Localization To Membrane Neuron Development Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Synapse Protein Localization To Plasma Membrane Cellular Component Assembly Protein Localization Cellular Protein Localization Neuron Projection Morphogenesis Nervous System Development Neuron Differentiation Regulation Of Catalytic Activity Signaling Cellular Localization Cell Morphogenesis Involved In Differentiation Cell Communication Axonogenesis Cell Development Response To External Stimulus Anatomical Structure Development Locomotion Plasma Membrane Organization Neurotransmitter Secretion Protein Complex Assembly System Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Endomembrane System Organization Regulation Of Neurotransmitter Levels Cell-cell Signaling Receptor Localization To Synapse Movement Of Cell Or Subcellular Component Developmental Process Apoptotic Process Generation Of Neurons Neurotransmitter Transport	Cysteine Biosynthetic Process From Serine Homocysteine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Transsulfuration Cysteine Biosynthetic Process L-cysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process L-serine Catabolic Process Interleukin-1 Beta Secretion Hydrogen Sulfide Metabolic Process Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Cysteine Metabolic Process Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Homocysteine Metabolic Process Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Platelet Dense Granule Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Phospholipid Efflux Phagocytosis, Engulfment Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Hematopoietic Stem Cell Proliferation Sulfur Amino Acid Catabolic Process Serine Family Amino Acid Catabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Membrane Invagination Reverse Cholesterol Transport Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux L-serine Metabolic Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cdc42 Protein Signal Transduction Regulation Of The Force Of Heart Contraction Protein K63-linked Ubiquitination
Tagcloud ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	abnormality defect disrupting ectopic endoplasmic enhances galnt12 glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin unfolded unsolved upr
Tagcloud (Difference) ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	abnormality defect disrupting ectopic endoplasmic enhances galnt12 glycoproteins glycosylation h3k4 h6pd hrx leukemogenesis lineage mammals maturation mef methyltransferase mll1 named promoters restore subject tm trimethylation tunicamycin unfolded unsolved upr
Tagcloud (Intersection) ?