ABCA1 and PDLIM4

Number of citations of the paper that reports this interaction (PMID 16192286)
14

Data Source:
HPRD (in vitro)

		ABCA1	PDLIM4
Gene Name		ATP-binding cassette, sub-family A (ABC1), member 1	PDZ and LIM domain 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle High-density Lipoprotein Particle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Protein Binding ATP Binding Phospholipid Binding Phospholipid Transporter Activity Anion Transmembrane Transporter Activity Cholesterol Binding ATPase Activity Cholesterol Transporter Activity Syntaxin Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Binding	Protein Binding Zinc Ion Binding
	Biological Process	Peptide Secretion Protein Lipidation Phagocytosis, Engulfment Lysosome Organization G-protein Coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Positive Regulation Of CAMP Biosynthetic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Phospholipid Translocation Interleukin-1 Beta Secretion Phospholipid Homeostasis Response To Low-density Lipoprotein Particle Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport
Drugs		Adenosine triphosphate Glyburide Probucol
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 21909109 18193043 18193044 20864672 19060906 23505323 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) MRI atrophy measures ( 21116278) Myopia (pathological) ( 23049088)	Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		42 interactors: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBB2IP FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2 XPC	5 interactors: ABCA1 PTPN13 RBPMS TRIP6 ZNF408
Entrez ID		19	8572
HPRD ID		02501	04571
Ensembl ID		ENSG00000165029	ENSG00000131435
Uniprot IDs		B2RUU2 B7XCW9 O95477	P50479
PDB IDs			2EEG 2V1W
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Chemotaxis Neuron Projection Development Maintenance Of Cell Polarity Cell Projection Organization Protein Localization To Membrane Neuron Development Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Synapse Protein Localization To Plasma Membrane Cellular Component Assembly Protein Localization Cellular Protein Localization Neuron Projection Morphogenesis Nervous System Development Neuron Differentiation Regulation Of Catalytic Activity Signaling Cellular Localization Cell Morphogenesis Involved In Differentiation Cell Communication Axonogenesis Cell Development Response To External Stimulus Anatomical Structure Development Locomotion Plasma Membrane Organization Neurotransmitter Secretion Protein Complex Assembly System Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Endomembrane System Organization Regulation Of Neurotransmitter Levels Cell-cell Signaling Receptor Localization To Synapse Movement Of Cell Or Subcellular Component Developmental Process Apoptotic Process Generation Of Neurons Neurotransmitter Transport	Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Interleukin-1 Beta Secretion Regulation Of Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Intracellular Transport Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Regulation Of Intracellular Protein Transport Regulation Of Signaling Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Positive Regulation Of Protein Transport Platelet Dense Granule Organization Cellular Macromolecule Biosynthetic Process Phospholipid Efflux Phagocytosis, Engulfment Macromolecule Biosynthetic Process Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Intracellular Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Regulation Of SMAD Protein Import Into Nucleus Membrane Invagination Reverse Cholesterol Transport Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Regulation Of Protein Transport
Tagcloud ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	adjacent benign c21orf63 distinguish done fabp5 flj14084 gstp1 hypermethylation implicating kiaa1210 methylation microarrays mlp panel prima1 profiling prostate ptgs2 quantitative sensitivities sorbs1 sox4 specificities svil taqman tissues tu3a u133
Tagcloud (Difference) ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	adjacent benign c21orf63 distinguish done fabp5 flj14084 gstp1 hypermethylation implicating kiaa1210 methylation microarrays mlp panel prima1 profiling prostate ptgs2 quantitative sensitivities sorbs1 sox4 specificities svil taqman tissues tu3a u133
Tagcloud (Intersection) ?