SHANK1 and ADGRB2

Number of citations of the paper that reports this interaction (PubMedID 10964907)
0

Data Source:
HPRD (two hybrid)

		SHANK1	ADGRB2
Description		SH3 and multiple ankyrin repeat domains 1	adhesion G protein-coupled receptor B2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Plasma Membrane Membrane Synapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding SH3 Domain Binding Signaling Receptor Complex Adaptor Activity Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Density	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Nervous System Development Long-term Memory Associative Learning Cell Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Cognition Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior AMPA Selective Glutamate Receptor Signaling Pathway Maintenance Of Postsynaptic Density Structure Positive Regulation Of Excitatory Postsynaptic Potential	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Peripheral Nervous System Development Negative Regulation Of Angiogenesis Calcineurin-NFAT Signaling Cascade Positive Regulation Of Synapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Asthma ( 31959851) Intraocular pressure ( 29617998 29785010) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)
Interacting Genes		23 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 PRMT2 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8	9 interacting genes: ARHGAP1 DLG4 GABPB1 HDHD2 LRP2BP SHANK1 SHANK2 SNTA1 STARD13
Entrez ID		50944	576
HPRD ID		05413	04063
Ensembl ID		ENSG00000161681	ENSG00000121753
Uniprot IDs		H9KV90 Q9Y566	A2A3C1 O60241
PDB IDs		6CPI 6YWZ 6YX0 6YX1 6YX2 7A00 8S1R	8OEK
Enriched GO Terms of Interacting Partners?		Synapse Postsynaptic Density Neuron Projection Regulation Of Cellular Component Organization Neuron Spine Glutamatergic Synapse Signal Transduction Dendritic Spine Latrotoxin Receptor Activity Cell Projection Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Postsynapse AMPA Glutamate Receptor Clustering Neuron Projection Organization Ribosomal Protein S6 Kinase Activity Postsynapse Organization Regulation Of Postsynapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Synapse Organization Chemical Synaptic Transmission Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling TORC1 Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Plasma Membrane Scaffold Protein Binding Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Positive Regulation Of Signal Transduction Neurotransmitter-gated Ion Channel Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Axon Regulation Of Signal Transduction PDZ Domain Binding Costamere Cytosol TOR Signaling Regulation Of Biological Quality Positive Regulation Of Developmental Process Postsynaptic Membrane	Vocalization Behavior Ionotropic Glutamate Receptor Binding Learning Synaptic Receptor Adaptor Activity Social Behavior Learning Or Memory Associative Learning Cognition SH3 Domain Binding Dendritic Spine Morphogenesis Dendritic Spine Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Ligand-gated Ion Channel Signaling Pathway Neuron Projection Organization Postsynapse Organization Postsynaptic Membrane Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Postsynaptic Density Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis P2Y1 Nucleotide Receptor Binding Protein Localization To Synapse Determination Of Affect Somatostatin Receptor Binding Scaffold Protein Binding Negative Regulation Of Endothelial Cell Migration Neuron Projection Neuromuscular Junction Protein Localization To Cell Junction PDZ Domain Binding Endothelial Tube Lumen Extension System Process Negative Regulation Of Endocytic Recycling Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Nervous System Process Lactose Synthase Activity Structural Constituent Of Postsynaptic Density Regulation Of Nervous System Process Regulation Of Membrane Potential Neuromuscular Process Syntrophin Complex N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity
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