ABCA1 and LMO7

Number of citations of the paper that reports this interaction (PMID 16192285)
1

Data Source:
HPRD (in vitro)

		ABCA1	LMO7
Gene Name		ATP-binding cassette, sub-family A (ABC1), member 1	LIM domain 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle High-density Lipoprotein Particle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Cytoplasm Focal Adhesion
	Molecular Function	Receptor Binding Protein Binding ATP Binding Phospholipid Binding Phospholipid Transporter Activity Anion Transmembrane Transporter Activity Cholesterol Binding ATPase Activity Cholesterol Transporter Activity Syntaxin Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding
	Biological Process	Peptide Secretion Protein Lipidation Phagocytosis, Engulfment Lysosome Organization G-protein Coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Positive Regulation Of CAMP Biosynthetic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Phospholipid Translocation Interleukin-1 Beta Secretion Phospholipid Homeostasis Response To Low-density Lipoprotein Particle Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol	Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport
Drugs		Adenosine triphosphate Glyburide Probucol
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 21909109 18193043 18193044 20864672 19060906 23505323 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) MRI atrophy measures ( 21116278) Myopia (pathological) ( 23049088)	Type 1 diabetes ( 21980299)
Protein-Protein Interactions		42 interactors: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBB2IP FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2 XPC	8 interactors: ABCA1 CALM1 EMD MDM2 PKM UBAC2 YWHAG YWHAQ
Entrez ID		19	4008
HPRD ID		02501	05078
Ensembl ID		ENSG00000165029	ENSG00000136153
Uniprot IDs		B2RUU2 B7XCW9 O95477	E9PLH4 J3KP06 Q8WWI1
PDB IDs			2EAQ
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Chemotaxis Neuron Projection Development Maintenance Of Cell Polarity Cell Projection Organization Protein Localization To Membrane Neuron Development Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Synapse Protein Localization To Plasma Membrane Cellular Component Assembly Protein Localization Cellular Protein Localization Neuron Projection Morphogenesis Nervous System Development Neuron Differentiation Regulation Of Catalytic Activity Signaling Cellular Localization Cell Morphogenesis Involved In Differentiation Cell Communication Axonogenesis Cell Development Response To External Stimulus Anatomical Structure Development Locomotion Plasma Membrane Organization Neurotransmitter Secretion Protein Complex Assembly System Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Endomembrane System Organization Regulation Of Neurotransmitter Levels Cell-cell Signaling Receptor Localization To Synapse Movement Of Cell Or Subcellular Component Developmental Process Apoptotic Process Generation Of Neurons Neurotransmitter Transport	Positive Regulation Of Transport Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Membrane Organization Regulation Of Cellular Localization Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Protein Export From Nucleus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Substantia Nigra Development Regulation Of Protein Localization Regulation Of Signaling Cellular Response To Organic Substance Neural Nucleus Development Protein Localization Positive Regulation Of Mitochondrion Organization Positive Regulation Of CAMP Biosynthetic Process Programmed Cell Death Positive Regulation Of CAMP Metabolic Process Cell Death Death Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To UV-C Cellular Response To Vitamin B1 Midbrain Development Regulation Of CAMP Biosynthetic Process Cellular Response To Light Stimulus Regulation Of Mitochondrion Organization Regulation Of CAMP Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Response To Organic Substance Cellular Protein Localization Cellular Response To Growth Factor Stimulus Response To Growth Factor Establishment Of Protein Localization Cellular Response To Radiation Glucose Metabolic Process Carbohydrate Catabolic Process Mitotic Cell Cycle Process Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Traversing Start Control Point Of Mitotic Cell Cycle Interleukin-1 Beta Secretion Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway
Tagcloud ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	bcrp c9orf3 cassette cdyl chemotherapeutics chemotherapies conferred ctrl devised dock ehbp1 farnesol farnesylation farnesyltransferase foxa2 functionalized ine1 isoprenoid mdr1 mrp1 mrs2 neb numbl oils oncoproteins pharmacogenomic sesquiterpene stab2 urgently
Tagcloud (Difference) ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	bcrp c9orf3 cassette cdyl chemotherapeutics chemotherapies conferred ctrl devised dock ehbp1 farnesol farnesylation farnesyltransferase foxa2 functionalized ine1 isoprenoid mdr1 mrp1 mrs2 neb numbl oils oncoproteins pharmacogenomic sesquiterpene stab2 urgently
Tagcloud (Intersection) ?