SHANK1 and TANC1

Number of citations of the paper that reports this interaction (PubMedID 15673434)
0

Data Source:
HPRD (in vitro)

		SHANK1	TANC1
Description		SH3 and multiple ankyrin repeat domains 1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Postsynaptic Density Dendrite Neuronal Cell Body Axon Terminus Synapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding SH3 Domain Binding Signaling Receptor Complex Adaptor Activity Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Density	Protein Binding
	Biological Process	Nervous System Development Long-term Memory Associative Learning Cell Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Cognition Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior AMPA Selective Glutamate Receptor Signaling Pathway Maintenance Of Postsynaptic Density Structure Positive Regulation Of Excitatory Postsynaptic Potential	Myoblast Fusion Visual Learning Dendritic Spine Maintenance Regulation Of Postsynapse Organization
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 28869591 30598549) Nicotine dependence ( 28440896) Night sleep phenotypes ( 27126917) Response to radiotherapy in prostate cancer (toxicity) ( 24974847) Resting heart rate ( 27798624) Restless legs syndrome ( 29029846) Tourette syndrome ( 30818990)
Interacting Genes		23 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 PRMT2 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8	12 interacting genes: ACTB CAMK2A CASK DLG1 DLG4 DLGAP1 GRIA1 GRIN2B HOMER1 INA SHANK1 SPTAN1
Entrez ID		50944	85461
HPRD ID		05413	18146
Ensembl ID		ENSG00000161681	ENSG00000115183
Uniprot IDs		H9KV90 Q9Y566	B9EK39 Q9C0D5
PDB IDs		6CPI 6YWZ 6YX0 6YX1 6YX2 7A00 8S1R
Enriched GO Terms of Interacting Partners?		Synapse Postsynaptic Density Neuron Projection Regulation Of Cellular Component Organization Neuron Spine Glutamatergic Synapse Signal Transduction Dendritic Spine Latrotoxin Receptor Activity Cell Projection Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Postsynapse AMPA Glutamate Receptor Clustering Neuron Projection Organization Ribosomal Protein S6 Kinase Activity Postsynapse Organization Regulation Of Postsynapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Synapse Organization Chemical Synaptic Transmission Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling TORC1 Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Plasma Membrane Scaffold Protein Binding Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Positive Regulation Of Signal Transduction Neurotransmitter-gated Ion Channel Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Axon Regulation Of Signal Transduction PDZ Domain Binding Costamere Cytosol TOR Signaling Regulation Of Biological Quality Positive Regulation Of Developmental Process Postsynaptic Membrane	Postsynaptic Density Modulation Of Chemical Synaptic Transmission Synapse Glutamate Receptor Signaling Pathway Neuron Projection Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Neuron Spine Ligand-gated Ion Channel Signaling Pathway Glutamatergic Synapse Chemical Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Dendritic Spine Trans-synaptic Signaling Synaptic Signaling Synaptic Membrane Regulation Of Monoatomic Ion Transport Protein Localization To Cell Junction Dendrite Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding Regulation Of Nervous System Process Excitatory Synapse Structural Constituent Of Postsynaptic Density Cell-cell Signaling Regulation Of Transport Signaling Positive Regulation Of Synaptic Transmission Cell Communication Maintenance Of Postsynaptic Density Structure Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Monoatomic Ion Transport Long-term Synaptic Potentiation Regulation Of Membrane Potential Regulation Of Neuronal Synaptic Plasticity Protein Localization To Synapse Cell Junction Cell-cell Junction Regulation Of Synaptic Plasticity Glutamate Receptor Binding Postsynapse Scaffold Protein Binding Postsynaptic Membrane GMP Kinase Activity Glutamate-gated Calcium Ion Channel Activity Endocytic Vesicle Membrane Maintenance Of Postsynaptic Specialization Structure Neuromuscular Junction
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