ABCA1 and MPDZ

Number of citations of the paper that reports this interaction (PMID 16192269)
10

Data Source:
HPRD (in vitro)

		ABCA1	MPDZ
Gene Name		ATP-binding cassette, sub-family A (ABC1), member 1	multiple PDZ domain protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle High-density Lipoprotein Particle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cytoplasmic Vesicle Schmidt-Lanterman Incisure Postsynaptic Membrane
	Molecular Function	Receptor Binding Protein Binding ATP Binding Phospholipid Binding Phospholipid Transporter Activity Anion Transmembrane Transporter Activity Cholesterol Binding ATPase Activity Cholesterol Transporter Activity Syntaxin Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Peptide Secretion Protein Lipidation Phagocytosis, Engulfment Lysosome Organization G-protein Coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Positive Regulation Of CAMP Biosynthetic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Phospholipid Translocation Interleukin-1 Beta Secretion Phospholipid Homeostasis Response To Low-density Lipoprotein Particle Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol	Cell Adhesion Viral Process Myelination
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport
Drugs		Adenosine triphosphate Glyburide Probucol
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 21909109 18193043 18193044 20864672 19060906 23505323 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) MRI atrophy measures ( 21116278) Myopia (pathological) ( 23049088)	Corneal structure ( 23291589)
Protein-Protein Interactions		42 interactors: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBB2IP FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2 XPC	13 interactors: ABCA1 CAMK2A CLDN1 CLDN5 CSPG4 DRD3 F11R HTR2C KIT PLEKHA1 PLEKHA2 RNF5 SYNGAP1
Entrez ID		19	8777
HPRD ID		02501	09155
Ensembl ID		ENSG00000165029	ENSG00000107186
Uniprot IDs		B2RUU2 B7XCW9 O95477	F5H1U9 O75970
PDB IDs			2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Chemotaxis Neuron Projection Development Maintenance Of Cell Polarity Cell Projection Organization Protein Localization To Membrane Neuron Development Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Synapse Protein Localization To Plasma Membrane Cellular Component Assembly Protein Localization Cellular Protein Localization Neuron Projection Morphogenesis Nervous System Development Neuron Differentiation Regulation Of Catalytic Activity Signaling Cellular Localization Cell Morphogenesis Involved In Differentiation Cell Communication Axonogenesis Cell Development Response To External Stimulus Anatomical Structure Development Locomotion Plasma Membrane Organization Neurotransmitter Secretion Protein Complex Assembly System Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Endomembrane System Organization Regulation Of Neurotransmitter Levels Cell-cell Signaling Receptor Localization To Synapse Movement Of Cell Or Subcellular Component Developmental Process Apoptotic Process Generation Of Neurons Neurotransmitter Transport	Regulation Of Intracellular Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Signaling Visual Learning Visual Behavior Associative Learning Regulation Of Synaptic Transmission Regulation Of Signal Transduction Learning Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Radiation Single-organism Behavior Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Permeability Response To Abiotic Stimulus Negative Regulation Of Protein Kinase B Signaling Behavior Regulation Of MAPK Cascade Cellular Response To Stimulus Signal Transduction Learning Or Memory Cognition Negative Regulation Of Cell Differentiation Regulation Of Lipid Metabolic Process Homeostatic Process Rhythmic Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Signaling Response To Light Stimulus Cell Communication Membrane Organization Chemical Homeostasis Positive Regulation Of Metabolic Process Cellular Localization Response To Stress Regulation Of Cell Differentiation Regulation Of CAMP Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sodium:proton Antiporter Activity Regulation Of Corticotropin-releasing Hormone Secretion Gastric Emptying Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway
Tagcloud ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	a4 ace2 affective affectivity bonferroni combine converting correction endoperoxide exceeded gated nociceptive nonspecific oppera orofacial phenotypes prostaglandin ptgs1 rs10809907 rs1514280 rs3842803 rs466448 rs6432860 scn1a summation temporomandibular thresholds tmd
Tagcloud (Difference) ?		administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave	a4 ace2 affective affectivity bonferroni combine converting correction endoperoxide exceeded gated nociceptive nonspecific oppera orofacial phenotypes prostaglandin ptgs1 rs10809907 rs1514280 rs3842803 rs466448 rs6432860 scn1a summation temporomandibular thresholds tmd
Tagcloud (Intersection) ?