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SHANK1 and ARHGEF7
Number of citations of the paper that reports this interaction (PMID
12626503
)
31
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, two hybrid, in vitro)
SHANK1
ARHGEF7
Gene Name
SH3 and multiple ankyrin repeat domains 1
Rho guanine nucleotide exchange factor (GEF) 7
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Cytoplasm
Plasma Membrane
Ionotropic Glutamate Receptor Complex
Membrane
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Neuron Projection
Dendritic Spine
Postsynaptic Membrane
Excitatory Synapse
Neuronal Postsynaptic Density
Ruffle
Cytosol
Focal Adhesion
Cell Cortex
Lamellipodium
Neuron Projection
Neuronal Cell Body
Protein Complex
Molecular Function
Protein Binding
Protein C-terminus Binding
SH3 Domain Binding
GKAP/Homer Scaffold Activity
Somatostatin Receptor Binding
Protein Complex Binding
Ionotropic Glutamate Receptor Binding
Identical Protein Binding
Ankyrin Repeat Binding
Scaffold Protein Binding
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Kinase Binding
Biological Process
Protein Complex Assembly
Cytoskeletal Anchoring At Plasma Membrane
Long-term Memory
Associative Learning
Adult Behavior
Negative Regulation Of Actin Filament Bundle Assembly
Social Behavior
Protein Localization To Synapse
Olfactory Behavior
Habituation
Neuromuscular Process Controlling Balance
Determination Of Affect
Righting Reflex
Synapse Maturation
Dendritic Spine Morphogenesis
Positive Regulation Of Dendritic Spine Development
Vocalization Behavior
Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Hematopoietic Progenitor Cell Differentiation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Fibroblast Migration
Lamellipodium Assembly
Positive Regulation Of Rac GTPase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Lamellipodium Morphogenesis
Pathways
EGFR downregulation
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Ligand-Responsive EGFR Variants in Cancer
p75 NTR receptor-mediated signalling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Rho GTPase cycle
Signaling by EGFR
GPCR downstream signaling
Ephrin signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
Signaling by EGFR in Cancer
EPH-Ephrin signaling
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Bilirubin levels (
19414484
)
Menarche (age at onset) (
21102462
)
Menopause (age at onset) (
19448619
)
Protein-Protein Interactions
17 interactors:
ABCA1
ARHGEF7
BAI2
BAIAP2
DLG4
DLGAP1
DNM2
HOMER1
LPHN1
LPHN2
RPS6KA2
RPS6KA3
SHARPIN
SPTAN1
SSTR2
STAT1
TANC1
28 interactors:
ADAM15
ARHGEF6
CALM1
CBLB
CD244
CDC42
ERBB2IP
GIT1
GIT2
LRRK2
MEOX2
NCK1
NCKIPSD
PAK1
PAK2
PAK3
PPM1E
PPM1F
PXN
RAC1
SCRIB
SH2D1A
SHANK1
SHANK2
TGFBR2
TUBB3
WAS
YWHAG
Entrez ID
50944
8874
HPRD ID
05413
05688
Ensembl ID
ENSG00000161681
ENSG00000102606
Uniprot IDs
H9KV90
Q9Y566
B7Z6G2
E9PDQ5
Q14155
PDB IDs
1BY1
1ZSG
2L3G
Enriched GO Terms of Interacting Partners
?
Synaptic Transmission
Neuron Projection Morphogenesis
Cell Projection Organization
Signaling
Nervous System Development
Cell Communication
Neuron Projection Development
Cell Projection Morphogenesis
Cell Part Morphogenesis
Cell Surface Receptor Signaling Pathway
Axonogenesis
Response To External Stimulus
Anatomical Structure Development
Cell-cell Signaling
Axon Development
Regulation Of Cellular Component Organization
System Development
Cell Morphogenesis Involved In Neuron Differentiation
Neuron Development
Cell Differentiation
Signal Transduction
Cell Morphogenesis
Developmental Process
Axon Guidance
Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Response To Stimulus
Multicellular Organismal Development
Cell Development
Apoptotic Process
Cellular Response To Stimulus
Programmed Cell Death
Chemotaxis
Generation Of Neurons
Cell Death
Death
Protein Localization To Synapse
Neurogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Dendritic Spine Organization
G-protein Coupled Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Response To Organic Substance
Cellular Response To Organic Substance
Regulation Of Cell Morphogenesis
Enzyme Linked Receptor Protein Signaling Pathway
Response To Bacterium
Neurotrophin TRK Receptor Signaling Pathway
Response To Nutrient
Neurotrophin Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Catalytic Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Kinase Activity
Regulation Of Signaling
Cell Morphogenesis
Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Phosphorylation
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Programmed Cell Death
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Death
Regulation Of Cell Adhesion
Regulation Of T Cell Activation
Neuron Projection Morphogenesis
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Organelle Organization
Positive Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Cell Development
Movement Of Cell Or Subcellular Component
Regulation Of Cytoskeleton Organization
Positive Regulation Of T Cell Activation
Neuron Development
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Actin Cytoskeleton Organization
Nervous System Development
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Immune System Process
Positive Regulation Of Transferase Activity
Axon Guidance
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Anatomical Structure Morphogenesis
Regulation Of Actin Filament-based Process
Neuron Projection Development
Tagcloud
?
akap6
atf7
atxn1
bmpr2
categorize
deltan
eef1a1
grip2
gtf2f1
interactors
jbd
jbds
jnk1alpha1
jnk3
jnk3alpha1
jnks
kcne4
myo9b
nnat
pias1
ptgds
ptpn2
rabgap1
rusc2
sumo1
sypl1
tkt
topbp1
znf668
Tagcloud (Difference)
?
akap6
atf7
atxn1
bmpr2
categorize
deltan
eef1a1
grip2
gtf2f1
interactors
jbd
jbds
jnk1alpha1
jnk3
jnk3alpha1
jnks
kcne4
myo9b
nnat
pias1
ptgds
ptpn2
rabgap1
rusc2
sumo1
sypl1
tkt
topbp1
znf668
Tagcloud (Intersection)
?