ABCA1 and DLG5

Number of citations: 50 (PubMedID 16192281)
Data Source: HPRD (in vitro)

		ABCA1	DLG5
Name		ATP binding cassette subfamily A member 1	discs large MAGUK scaffold protein 5
Structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Intracellular Vesicle	Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Membrane Cell Junction Ciliary Basal Body Cell Projection Synapse Anchoring Junction Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Signaling Receptor Binding Protein Binding ATP Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Protein Transmembrane Transporter Activity Cholesterol Binding ATP Hydrolysis Activity Syntaxin Binding Phosphatidylcholine Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase-coupled Transmembrane Transporter Activity Sphingolipid Floppase Activity ATPase Binding Phosphatidylcholine Floppase Activity Phosphatidylserine Floppase Activity Cholesterol Transfer Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Peptide Secretion Lipid Metabolic Process Phagocytosis, Engulfment Lysosome Organization G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process Cholesterol Metabolic Process Protein Secretion Response To Xenobiotic Stimulus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Organic Hydroxy Compound Transport Phospholipid Transport Endosomal Transport Signal Release Cholesterol Transport Response To Nutrient Levels Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Response To Vitamin B3 Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Phospholipid Translocation Establishment Of Localization In Cell Transmembrane Transport Phospholipid Homeostasis Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cytokine Stimulus Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Xenobiotic Stimulus Protein Transmembrane Transport Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Export Across Plasma Membrane	Epithelial To Mesenchymal Transition Establishment Or Maintenance Of Cell Polarity Signal Transduction Negative Regulation Of Cell Population Proliferation Tissue Development Positive Regulation Of Signal Transduction Glial Cell Differentiation Maintenance Of Cell Polarity Cell Differentiation Negative Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Midbrain Development Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Smoothened Signaling Pathway Animal Organ Development Regulation Of Multicellular Organismal Process Positive Regulation Of Synapse Assembly Epithelial Tube Branching Involved In Lung Morphogenesis Neuroepithelial Cell Differentiation Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Protein Localization To Adherens Junction Metanephric Collecting Duct Development Cell-cell Adhesion Postsynapse Organization
Pathways		PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs		ATP Glyburide Probucol	None
Diseases		Tangier disease Hypoalphalipoproteinemia	None
GWAS		A body shape index ( 34021172 ) Advanced age-related macular degeneration ( 26691988 ) Allergic rhinitis ( 25085501 ) Aluminium levels ( 26025379 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Cardiometabolic and hematological traits ( 27668658 ) Cholesterol, total ( 20686565 24097068 25961943 26582766 ) Coronary artery disease ( 29212778 33020668 ) Glaucoma ( 30054594 31959993 ) Glaucoma (high intraocular pressure) ( 25173107 ) Glaucoma (multi-trait analysis) ( 31959993 ) Glaucoma (primary open-angle) ( 25173105 29452408 29891935 33627673 ) Gout ( 22179738 ) HDL cholesterol ( 18193043 18193044 19060906 19060911 20686565 20864672 21347282 21909109 23505323 24097068 25961943 26160806 26582766 26780889 28270201 30275531 ) HDL cholesterol levels ( 26690388 28334899 30698716 31087446 31694877 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) High density lipoprotein cholesterol levels ( 29403010 29615537 30718733 33339817 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Intraocular pressure ( 25173106 28073927 29235454 29617998 29785010 30054594 30591961 31798171 31959993 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Lipid metabolism phenotypes ( 22286219 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Low high density lipoprotein cholesterol levels ( 26879886 ) Lung cancer in ever smokers ( 28604730 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolic syndrome ( 22399527 30382898 31589552 ) Metabolite levels ( 22916037 31628463 ) Myopia (pathological) ( 23049088 ) Pelvic organ prolapse ( 26545240 ) Periodontitis (Mean PAL) ( 24024966 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systemic mastocytosis ( 32752121 ) Total cholesterol levels ( 28334899 29403010 30275531 31087446 33339817 ) Triglyceride levels ( 32154731 32203549 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 ) Type 2 diabetes ( 32499647 ) Urate levels ( 31578528 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500 ) Whole-brain volume (Alzheimer's disease interaction) ( 21116278 )	Alanine aminotransferase levels ( 33339817 33547301 34315874 ) Alanine transaminase levels ( 29403010 ) Aspartate aminotransferase levels ( 33547301 34315874 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514 ) Macular thickness ( 30535121 ) Obesity-related traits ( 23251661 ) Retinal detachment or retinal break ( 31816047 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		2 novel interactors: ERP44 INVS	None recorded
Interacting Genes		41 interacting genes: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBIN FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ PALS2 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2	8 interacting genes: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		19	9231
HPRD ID		02501	04972
Ensembl ID		ENSG00000165029	ENSG00000151208
Uniprot IDs		B2RUU2 B7XCW9 O95477	Q8TDM6
PDB IDs		5XJY 7ROQ 7TBW 7TBY 7TBZ 7TC0 7TDT	1UIT
GO Terms Enriched among Interactors		Anchoring Junction MPP7-DLG1-LIN7 Complex Synapse Plasma Membrane Neuromuscular Junction PDZ Domain Binding Regulation Of Synaptic Assembly At Neuromuscular Junction Neurotransmitter Secretion Postsynaptic Density Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Dystrophin-associated Glycoprotein Complex Cell-cell Junction Intracellular Protein Localization Bicellular Tight Junction Protein Kinase CK2 Complex L27 Domain Binding Protein-containing Complex Organization Basolateral Plasma Membrane Cellular Component Assembly Protein-containing Complex Assembly Establishment Or Maintenance Of Cell Polarity Signal Release Protein Localization To Cell Junction Ionotropic Glutamate Receptor Binding Synaptic Vesicle Transport Adherens Junction Neurotransmitter Transport Regulation Of Macroautophagy Establishment Of Vesicle Localization Neuron Projection Vesicle Localization Membrane High-density Lipoprotein Particle Assembly Postsynaptic Membrane Regulation Of Autophagy High-density Lipoprotein Particle Binding Cytoplasm Protein Localization To Synapse Postsynaptic Density Glutamatergic Synapse Regulation Of Monoatomic Anion Transport Small GTPase-mediated Signal Transduction Regulation Of Cell Junction Assembly Rho Protein Signal Transduction Muscle Alpha-actinin Binding Apical Protein Localization Regulation Of Cellular Component Organization Regulation Of Growth Cytoskeletal Protein Binding	Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein-containing Complex Assembly Focal Adhesion Positive Regulation Of Organelle Organization Cellular Response To Lipoprotein Particle Stimulus Basolateral Plasma Membrane Regulation Of Telomere Maintenance Via Telomerase Response To Xenobiotic Stimulus Cholesterol Binding Sphingolipid Floppase Activity Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Dihydrolipoyllysine-residue Succinyltransferase Activity Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Telomere Maintenance Response To Vitamin B3 Regulation Of Cell Communication Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of Intracellular Signal Transduction Apolipoprotein A-I Receptor Activity Regulation Of Protein-containing Complex Assembly Regulation Of Signaling Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Myoblast Fusion Involved In Skeletal Muscle Regeneration Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Renal Inner Medulla Development Scrib-APC-beta-catenin Complex