ZBTB25 and FCGR3A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZBTB25	FCGR3A
Description		zinc finger and BTB domain containing 25	Fc gamma receptor IIIa
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Fc-gamma Receptor III Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding IgG Receptor Activity Low-affinity IgG Receptor Activity IgG Binding Immune Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process	Antibody-dependent Cellular Cytotoxicity T Cell Mediated Cytotoxicity Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Protein Import Calcium-mediated Signaling Natural Killer Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Proliferation Fc-gamma Receptor Signaling Pathway Macrophage Activation Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Transmembrane Transport Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab Amivantamab
Diseases			NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
GWAS		Heel bone mineral density ( 30598549) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494)	Alanine aminotransferase levels ( 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Monocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 23830517 30498034) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908)
Interacting Genes		33 interacting genes: APIP COIL CRACR2B CYP2J2 CYSRT1 DDIT3 FCGR3A FHL2 HCLS1 HOMEZ HSBP1 KCTD1 KCTD9 KRTAP10-8 KRTAP17-1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 SUMO2 TBC1D5 TNIP1 TRAF2 TRAF6 TSSK3 VCP VMAC ZBTB1	20 interacting genes: APCS APP CD247 CD38 CD4 CFTR FCER1G FCGR1A GP6 IGHG1 LCK LXN PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25
Entrez ID		7597	2214
HPRD ID		01926	00903
Ensembl ID		ENSG00000089775	ENSG00000203747
Uniprot IDs		G3V2K3 P24278	H0Y755 P08637
PDB IDs			3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5 7SEG 7URU
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Post-translational Protein Modification CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of JUN Kinase Activity Interleukin-17-mediated Signaling Pathway Regulation Of Protein Deubiquitination Positive Regulation Of Protein Deubiquitination Amino Acid Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II MyD88-dependent Toll-like Receptor Signaling Pathway Signaling Adaptor Activity Protein Homooligomerization Negative Regulation Of DNA-templated Transcription Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Transcription Factor Binding Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Fc-epsilon Receptor Signaling Pathway Ubiquitin-like Protein Ligase Binding Regulation Of T Cell Mediated Immunity Translesion Synthesis Regulation Of Post-translational Protein Modification Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of MAPK Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of T Cell Cytokine Production Protein Complex Oligomerization Arachidonate 5,6-epoxygenase Activity Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress TORC2 Complex Disassembly Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Pro-T Cell Differentiation	Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Activation Adaptive Immune Response Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Complex Gamma-delta T Cell Activation Leukocyte Activation Activation Of Immune Response T Cell Differentiation Immune System Process Positive Regulation Of Endocytosis Positive Regulation Of MAPK Cascade Lymphocyte Activation T Cell Selection Defense Response To Bacterium T Cell Activation Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium-mediated Signaling Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Leukocyte Differentiation Defense Response Regulation Of Phagocytosis Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Vesicle-mediated Transport Response To Stress Immunoglobulin Mediated Immune Response Membrane Raft Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cytokine Production Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?