ZBTB25 and SSX3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZBTB25	SSX3
Description		zinc finger and BTB domain containing 25	SSX family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process	Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494)
Interacting Genes		33 interacting genes: APIP COIL CRACR2B CYP2J2 CYSRT1 DDIT3 FCGR3A FHL2 HCLS1 HOMEZ HSBP1 KCTD1 KCTD9 KRTAP10-8 KRTAP17-1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 SUMO2 TBC1D5 TNIP1 TRAF2 TRAF6 TSSK3 VCP VMAC ZBTB1	22 interacting genes: AGTRAP AKAP9 CBY2 CEP63 CEP70 CMTM4 CMTM5 DDIT3 KRT27 MED4 MEOX2 MIPOL1 PCBD2 PIH1D2 RABGEF1 RHOJ SSX2IP ZBTB25 ZBTB3 ZNF496 ZNG1A ZSCAN1
Entrez ID		7597	10214
HPRD ID		01926	02265
Ensembl ID		ENSG00000089775	ENSG00000165584
Uniprot IDs		G3V2K3 P24278	Q99909
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Post-translational Protein Modification CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of JUN Kinase Activity Interleukin-17-mediated Signaling Pathway Regulation Of Protein Deubiquitination Positive Regulation Of Protein Deubiquitination Amino Acid Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II MyD88-dependent Toll-like Receptor Signaling Pathway Signaling Adaptor Activity Protein Homooligomerization Negative Regulation Of DNA-templated Transcription Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Transcription Factor Binding Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Fc-epsilon Receptor Signaling Pathway Ubiquitin-like Protein Ligase Binding Regulation Of T Cell Mediated Immunity Translesion Synthesis Regulation Of Post-translational Protein Modification Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of MAPK Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of T Cell Cytokine Production Protein Complex Oligomerization Arachidonate 5,6-epoxygenase Activity Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress TORC2 Complex Disassembly Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Pro-T Cell Differentiation
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