ZBTB25 and CYP2J2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZBTB25	CYP2J2
Description		zinc finger and BTB domain containing 25	cytochrome P450 family 2 subfamily J member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Arachidonate 14,15-epoxygenase Activity Arachidonate 11,12-epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Isomerase Activity Heme Binding Metal Ion Binding Linoleic Acid Epoxygenase Activity Hydroperoxy Icosatetraenoate Isomerase Activity Arachidonate 5,6-epoxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process	Organic Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Xenobiotic Metabolic Process Regulation Of Heart Contraction Arachidonate Metabolic Process Epoxygenase P450 Pathway Linoleic Acid Metabolic Process
Pathways			Fatty acids Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494)	Alcoholic chronic pancreatitis ( 28754779) Night sleep phenotypes ( 27126917)
Interacting Genes		33 interacting genes: APIP COIL CRACR2B CYP2J2 CYSRT1 DDIT3 FCGR3A FHL2 HCLS1 HOMEZ HSBP1 KCTD1 KCTD9 KRTAP10-8 KRTAP17-1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 SUMO2 TBC1D5 TNIP1 TRAF2 TRAF6 TSSK3 VCP VMAC ZBTB1	2 interacting genes: ELOC ZBTB25
Entrez ID		7597	1573
HPRD ID		01926	03159
Ensembl ID		ENSG00000089775	ENSG00000134716
Uniprot IDs		G3V2K3 P24278	P51589
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Post-translational Protein Modification CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of JUN Kinase Activity Interleukin-17-mediated Signaling Pathway Regulation Of Protein Deubiquitination Positive Regulation Of Protein Deubiquitination Amino Acid Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II MyD88-dependent Toll-like Receptor Signaling Pathway Signaling Adaptor Activity Protein Homooligomerization Negative Regulation Of DNA-templated Transcription Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Transcription Factor Binding Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Fc-epsilon Receptor Signaling Pathway Ubiquitin-like Protein Ligase Binding Regulation Of T Cell Mediated Immunity Translesion Synthesis Regulation Of Post-translational Protein Modification Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of MAPK Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of T Cell Cytokine Production Protein Complex Oligomerization Arachidonate 5,6-epoxygenase Activity Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress TORC2 Complex Disassembly Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Pro-T Cell Differentiation	Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Target-directed MiRNA Degradation MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Elongin Complex Regulation Of Post-transcriptional Gene Silencing MiRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter
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