PC and LCOR

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PC	LCOR
Description		pyruvate carboxylase	ligand dependent nuclear receptor corepressor
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Catalytic Activity Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Identical Protein Binding Metal Ion Binding	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding
	Biological Process	Gluconeogenesis Lipid Metabolic Process NADP+ Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Viral Release From Host Cell NAD+ Metabolic Process Small Molecule Metabolic Process Host-mediated Activation Of Viral Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis Pyruvate metabolism
Drugs		Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases		Pyruvate carboxylase deficiency
GWAS		A body shape index ( 34021172) Bipolar disorder ( 21926972 31043756 34002096) Familial squamous cell lung carcinoma ( 29924316) Hip circumference adjusted for BMI ( 34021172) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)
Interacting Genes		7 interacting genes: FNDC3B GOT1 GOT2 LCOR MDH2 RNF10 USP7	144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE
Entrez ID		5091	84458
HPRD ID		02032	07609
Ensembl ID		ENSG00000173599	ENSG00000196233
Uniprot IDs		P11498	Q96JN0
PDB IDs		3BG3 3BG9 7WTA 7WTB 7WTC 7WTD 7WTE 8HWL 8J7O 8XL9	2COB 6V3X 6V3Y
Enriched GO Terms of Interacting Partners?		Malate-aspartate Shuttle L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process L-aspartate Catabolic Process NAD+ Metabolic Process Aspartate Metabolic Process Oxaloacetate Metabolic Process L-glutamate Catabolic Process Dicarboxylic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process 2-oxoglutarate Metabolic Process Dicarboxylic Acid Catabolic Process Transaminase Activity Glutamate Metabolic Process Aspartate Family Amino Acid Metabolic Process Pyridoxal Phosphate Binding Gluconeogenesis Hexose Biosynthetic Process Glutamine Family Amino Acid Metabolic Process L-glutamate Biosynthetic Process L-malate Dehydrogenase (NADP+) Activity Upper Tip-link Density Myosin VII Complex Amino Acid Biosynthetic Process Catalytic Activity RNA Binding Purine Nucleotide Metabolic Process Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process L-cysteine Transaminase Activity Phosphatidylserine Decarboxylase Activity Nucleotide Metabolic Process Amino Acid Catabolic Process Response To Transition Metal Nanoparticle L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Symbiont-mediated Disruption Of Host Cell PML Body Small Molecule Biosynthetic Process Carbohydrate Biosynthetic Process Glucose Metabolic Process Purine-containing Compound Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Phagolysosome Assembly Stereocilium Base Chondrocyte Development Involved In Endochondral Bone Morphogenesis Glycerol Biosynthetic Process Equilibrioception Postsynapse To Nucleus Signaling Pathway	Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding
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