PC

Description		pyruvate carboxylase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Gluconeogenesis Lipid Metabolic Process NADP+ Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Viral Release From Host Cell NAD+ Metabolic Process Small Molecule Metabolic Process Host-mediated Activation Of Viral Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis Pyruvate metabolism
Drugs		Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases		Pyruvate carboxylase deficiency
GWAS		A body shape index ( 34021172) Bipolar disorder ( 21926972 31043756 34002096) Familial squamous cell lung carcinoma ( 29924316) Hip circumference adjusted for BMI ( 34021172) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Novel Interacting Genes		3 novel interacting genes: MYO7A PCBP2 SERPINH1
Interacting Genes		7 interacting genes: FNDC3B GOT1 GOT2 LCOR MDH2 RNF10 USP7
Entrez ID		5091
HPRD ID		02032
Ensembl ID		ENSG00000173599
Uniprot IDs		P11498
PDB IDs		3BG3 3BG9 7WTA 7WTB 7WTC 7WTD 7WTE 8HWL 8J7O 8XL9
Enriched GO Terms of Interacting Partners?		Malate-aspartate Shuttle L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process L-aspartate Catabolic Process NAD+ Metabolic Process Aspartate Metabolic Process Oxaloacetate Metabolic Process L-glutamate Catabolic Process Dicarboxylic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process 2-oxoglutarate Metabolic Process Dicarboxylic Acid Catabolic Process Transaminase Activity Glutamate Metabolic Process Aspartate Family Amino Acid Metabolic Process Pyridoxal Phosphate Binding Gluconeogenesis Hexose Biosynthetic Process Glutamine Family Amino Acid Metabolic Process L-glutamate Biosynthetic Process L-malate Dehydrogenase (NADP+) Activity Upper Tip-link Density Myosin VII Complex Amino Acid Biosynthetic Process Catalytic Activity RNA Binding Purine Nucleotide Metabolic Process Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process L-cysteine Transaminase Activity Phosphatidylserine Decarboxylase Activity Nucleotide Metabolic Process Amino Acid Catabolic Process Response To Transition Metal Nanoparticle L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Symbiont-mediated Disruption Of Host Cell PML Body Small Molecule Biosynthetic Process Carbohydrate Biosynthetic Process Glucose Metabolic Process Purine-containing Compound Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Phagolysosome Assembly Stereocilium Base Chondrocyte Development Involved In Endochondral Bone Morphogenesis Glycerol Biosynthetic Process Equilibrioception Postsynapse To Nucleus Signaling Pathway
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