PC and GOT2

Number of citations of the paper that reports this interaction (PMID 8349677)
3

Data Source:
HPRD (in vitro)

		PC	GOT2
Gene Name		pyruvate carboxylase	glutamic-oxaloacetic transaminase 2, mitochondrial
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Biotin Carboxylase Activity Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Metal Ion Binding	L-aspartate:2-oxoglutarate Aminotransferase Activity Kynurenine-oxoglutarate Transaminase Activity Pyridoxal Phosphate Binding Poly(A) RNA Binding L-phenylalanine:2-oxoglutarate Aminotransferase Activity
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Pyruvate Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Lipid Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Pathogenesis Small Molecule Metabolic Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Cellular Amino Acid Biosynthetic Process Pathogenesis Fatty Acid Transport 4-hydroxyproline Catabolic Process Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Response To Ethanol L-kynurenine Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Gluconeogenesis Glucose metabolism Defective AMN causes hereditary megaloblastic anemia 1 Myoclonic epilepsy of Lafora Glycogen storage diseases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Metabolism of carbohydrates Biotin transport and metabolism Defects in vitamin and cofactor metabolism	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Amino acid synthesis and interconversion (transamination) Metabolism of carbohydrates Metabolism of amino acids and derivatives
Drugs		Pyruvic acid Biotin 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL	Pyridoxal Phosphate L-Aspartic Acid L-Glutamic Acid 4\'-Deoxy-4\'-Acetylyamino-Pyridoxal-5\'-Phosphate
Diseases
GWAS		Bipolar disorder ( 21926972) HIV-1 susceptibility ( 22174851)	Aortic root size ( 21223598) QT interval ( 19305408)
Protein-Protein Interactions		3 interactors: GOT1 GOT2 MDH2	10 interactors: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6
Entrez ID		5091	2806
HPRD ID		02032	00684
Ensembl ID		ENSG00000173599	ENSG00000125166
Uniprot IDs		P11498	E7ERW2 P00505
PDB IDs		3BG3 3BG9
Enriched GO Terms of Interacting Partners?		Oxaloacetate Metabolic Process Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Gluconeogenesis Hexose Biosynthetic Process Fumarate Metabolic Process Aspartate Catabolic Process Dicarboxylic Acid Metabolic Process Glutamate Catabolic Process Glucose Metabolic Process Aspartate Metabolic Process Carbohydrate Biosynthetic Process Pathogenesis Hexose Metabolic Process Dicarboxylic Acid Catabolic Process Monosaccharide Metabolic Process 2-oxoglutarate Metabolic Process Glutamate Metabolic Process Cellular Amino Acid Catabolic Process Carboxylic Acid Metabolic Process Carbohydrate Metabolic Process Cellular Amino Acid Biosynthetic Process Organic Acid Metabolic Process Carboxylic Acid Catabolic Process Cellular Carbohydrate Metabolic Process Glycerol Biosynthetic Process Alpha-amino Acid Metabolic Process 4-hydroxyproline Catabolic Process L-kynurenine Metabolic Process Small Molecule Metabolic Process L-methionine Biosynthetic Process From Methylthioadenosine Cellular Amino Acid Metabolic Process L-methionine Salvage Kynurenine Metabolic Process Fatty Acid Homeostasis NADH Metabolic Process Malate Metabolic Process Methionine Biosynthetic Process Methionine Metabolic Process 4-hydroxyproline Metabolic Process Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process Polyamine Metabolic Process Glycerol Metabolic Process Tricarboxylic Acid Cycle Sulfur Amino Acid Metabolic Process Citrate Metabolic Process Anion Homeostasis NAD Metabolic Process	Gluconeogenesis Hexose Biosynthetic Process Dicarboxylic Acid Metabolic Process Oxaloacetate Metabolic Process Glucose Metabolic Process Carbohydrate Biosynthetic Process Pathogenesis Hexose Metabolic Process Monosaccharide Metabolic Process Tricarboxylic Acid Metabolic Process Protein Deglutathionylation Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Fibril Organization Peptidyl-cysteine S-trans-nitrosylation Carboxylic Acid Metabolic Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Mesangial Cell-matrix Adhesion Negative Regulation Of Exo-alpha-sialidase Activity Organic Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Dendritic Cell Dendrite Assembly Regulation Of Fibril Organization Small Molecule Metabolic Process Negative Regulation Of Leukocyte Tethering Or Rolling Clathrin Coat Disassembly Peptidyl-cysteine S-nitrosylation Establishment Of T Cell Polarity Oxidation-reduction Process Negative Regulation Of Monocyte Differentiation Glutamate Catabolic Process Positive Regulation Of Dendritic Cell Chemotaxis Cellular Metabolic Process Positive Regulation Of Transport Viral MRNA Export From Host Cell Nucleus Glutamate Biosynthetic Process Cellular Protein Metabolic Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Locomotion Biotin Metabolic Process Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Dicarboxylic Acid Catabolic Process Chaperone-mediated Protein Complex Assembly Protein Folding Regulation Of Monocyte Differentiation Dendritic Cell Chemotaxis
Tagcloud ?		47d accordance acetyltransferase ar ara70 bridging caf classic cloning coactivator coactivators coordinate cos deduced differs du ele1 ele1alpha ele1beta glucocorticoid gr hela isoform leucine lncap nonallelic rfg steroid testis tfiib	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		47d accordance acetyltransferase ar ara70 bridging caf classic cloning coactivator coactivators coordinate cos deduced differs du ele1 ele1alpha ele1beta glucocorticoid gr hela isoform leucine lncap nonallelic rfg steroid testis tfiib	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Intersection) ?