PBX1 and PKNOX1

Number of citations of the paper that reports this interaction (PMID 9482740)
49

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		PBX1	PKNOX1
Gene Name		pre-B-cell leukemia homeobox 1	PBX/knotted 1 homeobox 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Transcription, DNA-templated Steroid Biosynthetic Process Sex Differentiation Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Maintenance Embryonic Hemopoiesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Thymus Development Embryonic Skeletal System Development	Angiogenesis Transcription From RNA Polymerase II Promoter T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Breast cancer (prognosis) ( 23319801) Height ( 20966902)	Biochemical measures ( 19260141) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Protein-Protein Interactions		24 interactors: CREBBP HOXA1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB7 HOXB8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PKNOX1 POU2F1 SMARCD3	15 interactors: APP HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 MEIS1 PAX6 PBX1 PBX2 POU2F1 RFX3 TLX1 VPS37C ZBTB3
Entrez ID		5087	5316
HPRD ID		08889	03653
Ensembl ID		ENSG00000185630	ENSG00000160199
Uniprot IDs		A8K5V0 H0YLB0 P40424 Q53YC7	E7EPN6 P55347 Q6PKH2 Q96I87
PDB IDs		1B72 1PUF	1X2N
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Embryonic Morphogenesis RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Pattern Specification Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Anterior/posterior Pattern Specification Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Organ Development Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Developmental Process Organ Morphogenesis Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Anatomical Structure Development Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Skeletal System Development System Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Skeletal System Morphogenesis Embryonic Limb Morphogenesis Embryonic Organ Development Negative Regulation Of Myeloid Cell Differentiation	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Pattern Specification Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Embryonic Morphogenesis Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organ Development Anterior/posterior Pattern Specification Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Embryo Development System Development Embryonic Organ Development Developmental Process Nitrogen Compound Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Skeletal System Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Cell Development Chordate Embryonic Development Negative Regulation Of Neuron Differentiation Embryo Development Ending In Birth Or Egg Hatching Transcription From RNA Polymerase II Promoter Rhombomere Development
Tagcloud ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	219a 5p aberration amongst confer consortium dys effectors enrichment epha4 epigenetic esr1 hsa ipa mcic microrna micrornas mind neuropsychological predicted psychiatric ranked respective schizophrenia searched sets strengthened thousands transcriptionally
Tagcloud (Difference) ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	219a 5p aberration amongst confer consortium dys effectors enrichment epha4 epigenetic esr1 hsa ipa mcic microrna micrornas mind neuropsychological predicted psychiatric ranked respective schizophrenia searched sets strengthened thousands transcriptionally
Tagcloud (Intersection) ?