PBX1 and HOXB8

Number of citations of the paper that reports this interaction (PMID 11571641)
11

Data Source:
HPRD (in vivo)

		PBX1	HOXB8
Gene Name		pre-B-cell leukemia homeobox 1	homeobox B8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Transcription, DNA-templated Steroid Biosynthetic Process Sex Differentiation Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Maintenance Embryonic Hemopoiesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Thymus Development Embryonic Skeletal System Development	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Grooming Behavior Adult Locomotory Behavior Anterior/posterior Pattern Specification Sensory Perception Of Pain Dorsal Spinal Cord Development Negative Regulation Of Myeloid Cell Differentiation Embryonic Skeletal System Morphogenesis
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Breast cancer (prognosis) ( 23319801) Height ( 20966902)
Protein-Protein Interactions		24 interactors: CREBBP HOXA1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB7 HOXB8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PKNOX1 POU2F1 SMARCD3	4 interactors: MEIS1 PBX1 PBX2 PBX3
Entrez ID		5087	3218
HPRD ID		08889	00851
Ensembl ID		ENSG00000185630	ENSG00000120068
Uniprot IDs		A8K5V0 H0YLB0 P40424 Q53YC7	I3L3R1 P17481 Q8N8T3
PDB IDs		1B72 1PUF
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Embryonic Morphogenesis RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Pattern Specification Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Anterior/posterior Pattern Specification Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Organ Development Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Developmental Process Organ Morphogenesis Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Anatomical Structure Development Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Skeletal System Development System Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Skeletal System Morphogenesis Embryonic Limb Morphogenesis Embryonic Organ Development Negative Regulation Of Myeloid Cell Differentiation	Proximal/distal Pattern Formation Pattern Specification Process Transcription, DNA-templated RNA Biosynthetic Process Posterior Compartment Specification Anterior Compartment Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Limb Morphogenesis RNA Metabolic Process Negative Regulation Of Neuron Differentiation Limb Development Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated Compartment Pattern Specification Negative Regulation Of Neurogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Generation Of Neurons Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Neurogenesis Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Cell Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Respiratory System Process Megakaryocyte Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Neuron Differentiation Skeletal System Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nervous System Development Dorsal Spinal Cord Development
Tagcloud ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	6c 6g c4 carbohydrate cd11b complement declined dendritic deposited fashion ficolin ficolins granular granulocytes granulocytic immature int intra lectin ly lysates macrophages masp neutrophilic orthologue producer sepsis stored supernatants
Tagcloud (Difference) ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	6c 6g c4 carbohydrate cd11b complement declined dendritic deposited fashion ficolin ficolins granular granulocytes granulocytic immature int intra lectin ly lysates macrophages masp neutrophilic orthologue producer sepsis stored supernatants
Tagcloud (Intersection) ?