PBX1 and MEIS2

Number of citations of the paper that reports this interaction (PMID 11279116)
20

Data Source:
BioGRID (pull down)

		PBX1	MEIS2
Gene Name		pre-B-cell leukemia homeobox 1	Meis homeobox 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Transcription, DNA-templated Steroid Biosynthetic Process Sex Differentiation Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Maintenance Embryonic Hemopoiesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Thymus Development Embryonic Skeletal System Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Transcription From RNA Polymerase II Promoter Response To Mechanical Stimulus Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Breast cancer (prognosis) ( 23319801) Height ( 20966902)	Hyperactive-impulsive symptoms ( 18821565) Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		24 interactors: CREBBP HOXA1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB7 HOXB8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PKNOX1 POU2F1 SMARCD3	14 interactors: ANXA1 APP ARNT2 C1orf94 CRBN DGCR6 HOXA13 HOXA9 LINC00238 OSGIN1 PBX1 SQSTM1 TRIM25 ZNHIT3
Entrez ID		5087	4212
HPRD ID		08889	03443
Ensembl ID		ENSG00000185630	ENSG00000134138
Uniprot IDs		A8K5V0 H0YLB0 P40424 Q53YC7	B3KPD8 B7Z6F6 O14770
PDB IDs		1B72 1PUF	3K2A
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Embryonic Morphogenesis RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Pattern Specification Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Anterior/posterior Pattern Specification Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Organ Development Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Developmental Process Organ Morphogenesis Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Anatomical Structure Development Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Skeletal System Development System Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Skeletal System Morphogenesis Embryonic Limb Morphogenesis Embryonic Organ Development Negative Regulation Of Myeloid Cell Differentiation	Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Embryonic Limb Morphogenesis Regulation Of Cell Cycle Process Gland Development Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Limb Development Response To Estrogen Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Developmental Process Regulation Of Cell Cycle G2/M Phase Transition Proximal/distal Pattern Formation Organ Development Regulation Of Transcription, DNA-templated Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Reproductive Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune System Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Forelimb Morphogenesis Sex Differentiation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Neutrophil Clearance Prostate Gland Development Multicellular Organismal Development Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Urogenital System Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Neutrophil Apoptotic Process Synaptic Growth At Neuromuscular Junction
Tagcloud ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	accumulative aldehyde aldh1a1 blots cbfb cxcl6 devastating diras diras3 feel glaucoma homeobox identifiable immunocytochemistry meshwork negatives pitx2 protocols pursued ranking samd5 sirnas statistic sterile subtle tm tms vis
Tagcloud (Difference) ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	accumulative aldehyde aldh1a1 blots cbfb cxcl6 devastating diras diras3 feel glaucoma homeobox identifiable immunocytochemistry meshwork negatives pitx2 protocols pursued ranking samd5 sirnas statistic sterile subtle tm tms vis
Tagcloud (Intersection) ?