PBX1 and HOXD10

Number of citations of the paper that reports this interaction (PubMedID 10523646)
65

Data Source:
HPRD (in vitro)

		PBX1	HOXD10
Description		PBX homeobox 1	homeobox D10
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytosol Transcription Repressor Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Eye Development Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Natural Killer Cell Differentiation Regulation Of DNA-templated Transcription Steroid Biosynthetic Process Brain Development Sex Differentiation Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Embryonic Hemopoiesis Regulation Of Cell Population Proliferation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Thymus Development Embryonic Organ Development Neuron Development Embryonic Skeletal System Development Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Single Fertilization Skeletal Muscle Tissue Development Adult Locomotory Behavior Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Regulation Of Gene Expression Spinal Cord Motor Neuron Cell Fate Specification Embryonic Limb Morphogenesis Forelimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Peripheral Nervous System Neuron Development Neuromuscular Process
Pathways		Transcriptional regulation of pluripotent stem cells Activation of anterior HOX genes in hindbrain development during early embryogenesis NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Congenital vertical talus
GWAS		A body shape index ( 34021172) Asthma ( 29273806) Breast cancer (prognosis) ( 23319801) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Early-onset Parkinson's disease ( 28256260) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 20966902) High myopia ( 33830181) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking status (current vs never) ( 33082346) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462) Kidney volume ( 34128465) Male-pattern baldness ( 28196072)
Interacting Genes		32 interacting genes: BRMS1L CDCA7L CREBBP EFHC1 FAM90A1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB5 HOXB7 HOXB8 HOXC5 HOXC8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PIN1 PKNOX1 POU2F1 SMARCD3 UBC	7 interacting genes: CREBBP EP300 GEMIN2 GMNN HMGB1 PBX1 RCHY1
Entrez ID		5087	3236
HPRD ID		08889	00867
Ensembl ID		ENSG00000185630	ENSG00000128710
Uniprot IDs		A8K5V0 P40424 Q53YC7	P28358
PDB IDs		1B72 1PUF
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Chromatin Regionalization Anterior/posterior Pattern Specification Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Animal Organ Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Anatomical Structure Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Embryonic Morphogenesis Regulation Of RNA Metabolic Process Embryonic Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Skeletal System Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleus Nucleoplasm Animal Organ Development Regulation Of Metabolic Process Proximal/distal Pattern Formation Developmental Process Embryonic Skeletal System Development Skeletal System Development Sequence-specific DNA Binding Chromatin Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Developmental Process Embryonic Limb Morphogenesis Gland Development Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation	DNA-binding Transcription Factor Binding Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Damaged DNA Binding P53 Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Nucleoplasm Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Activation Of Innate Immune Response Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation Transcription Regulator Complex Lymphocyte Differentiation Transcription Coregulator Binding DNA Damage Response Tau Protein Binding Transcription Coactivator Activity Positive Regulation Of Binding Transcription Coactivator Binding Positive Regulation Of Innate Immune Response Mononuclear Cell Differentiation Protein Destabilization Canonical NF-kappaB Signal Transduction Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Transcription Repressor Complex Regulation Of Carbohydrate Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Nucleic Acid Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Leukocyte Differentiation Histone Crotonyltransferase Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity
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