PBX1 and HOXB1

Number of citations of the paper that reports this interaction (PMID 10052460)
74

Data Source:
HPRD (in vitro)

		PBX1	HOXB1
Gene Name		pre-B-cell leukemia homeobox 1	homeobox B1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Heterodimerization Activity	DNA Binding Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Transcription, DNA-templated Steroid Biosynthetic Process Sex Differentiation Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Maintenance Embryonic Hemopoiesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Thymus Development Embryonic Skeletal System Development	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Pattern Specification Process Anterior/posterior Pattern Specification Rhombomere 4 Development Rhombomere 5 Development Facial Nerve Structural Organization Facial Nucleus Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Morphogenesis
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Breast cancer (prognosis) ( 23319801) Height ( 20966902)	Primary tooth development (number of teeth) ( 20195514)
Protein-Protein Interactions		24 interactors: CREBBP HOXA1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB7 HOXB8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PKNOX1 POU2F1 SMARCD3	8 interactors: CREBBP EP300 HMGB1 MEIS1 PAX6 PBX1 PKNOX2 SERPINA3
Entrez ID		5087	3211
HPRD ID		08889	00855
Ensembl ID		ENSG00000185630
Uniprot IDs		A8K5V0 H0YLB0 P40424 Q53YC7	P14653
PDB IDs		1B72 1PUF	1B72
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Embryonic Morphogenesis RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Pattern Specification Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Anterior/posterior Pattern Specification Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Organ Development Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Developmental Process Organ Morphogenesis Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Anatomical Structure Development Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Skeletal System Development System Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Skeletal System Morphogenesis Embryonic Limb Morphogenesis Embryonic Organ Development Negative Regulation Of Myeloid Cell Differentiation	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of Neuron Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Heat Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Stem Cell Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neurogenesis Regulation Of Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Stem Cell Differentiation Cell Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Cell Development Regulation Of DNA-templated Transcription In Response To Stress Organ Morphogenesis Positive Regulation Of Metabolic Process Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Type I Interferon Production Negative Regulation Of RNA Biosynthetic Process Embryo Development Histone H2B Acetylation Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Negative Regulation Of Apoptotic Cell Clearance Pancreatic A Cell Development Nervous System Development Transcription, DNA-templated Pattern Specification Process RNA Biosynthetic Process
Tagcloud ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	blastocyst chx cycloheximide embryo embryos establishment ezh2 fertilisation gata6 giant h3k27me2 hand1 homologue lethality microinjecting nanog novo oct4 outgrowth pluripotency preimplantation pronuclear restrict retardation sox2 tri trophoblast zeste zygotes
Tagcloud (Difference) ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	blastocyst chx cycloheximide embryo embryos establishment ezh2 fertilisation gata6 giant h3k27me2 hand1 homologue lethality microinjecting nanog novo oct4 outgrowth pluripotency preimplantation pronuclear restrict retardation sox2 tri trophoblast zeste zygotes
Tagcloud (Intersection) ?