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PBX1 and HOXA10
Number of citations of the paper that reports this interaction (PubMedID
12145285
)
0
Data Source:
HPRD
(in vivo)
PBX1
HOXA10
Description
PBX homeobox 1
homeobox A10
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
Transcription Corepressor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Histone Deacetylase Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Eye Development
Urogenital System Development
Branching Involved In Ureteric Bud Morphogenesis
Natural Killer Cell Differentiation
Regulation Of DNA-templated Transcription
Steroid Biosynthetic Process
Brain Development
Sex Differentiation
Cell Population Proliferation
Animal Organ Morphogenesis
Anterior/posterior Pattern Specification
Proximal/distal Pattern Formation
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cell Differentiation
Regulation Of Ossification
Adrenal Gland Development
Embryonic Limb Morphogenesis
Embryonic Hemopoiesis
Regulation Of Cell Population Proliferation
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Spleen Development
Thymus Development
Embryonic Organ Development
Neuron Development
Embryonic Skeletal System Development
Stem Cell Proliferation
Positive Regulation Of Stem Cell Proliferation
Skeletal System Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Spermatogenesis
Single Fertilization
Male Gonad Development
Anterior/posterior Pattern Specification
Proximal/distal Pattern Formation
Regulation Of Gene Expression
Embryonic Limb Morphogenesis
Prostate Gland Development
Response To Testosterone
Response To Estrogen
Positive Regulation Of Transcription By RNA Polymerase II
Uterus Development
Pathways
Transcriptional regulation of pluripotent stem cells
Activation of anterior HOX genes in hindbrain development during early embryogenesis
NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Calcitriol
Diseases
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
A body shape index (
34021172
)
Asthma (
29273806
)
Breast cancer (prognosis) (
23319801
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Early-onset Parkinson's disease (
28256260
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Height (
20966902
)
High myopia (
33830181
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Myopia (
27182965
)
Night sleep phenotypes (
27126917
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Response to methotrexate in juvenile idiopathic arthritis (
24709693
)
Smoking status (current vs never) (
33082346
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Dental caries (
23259602
)
Hypertension (
30487518
31879980
)
Mean arterial pressure (
30487518
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
32 interacting genes:
BRMS1L
CDCA7L
CREBBP
EFHC1
FAM90A1
HOXA10
HOXA5
HOXA9
HOXB1
HOXB5
HOXB7
HOXB8
HOXC5
HOXC8
HOXD10
HOXD4
HOXD9
KAT2A
MDM2
MEIS1
MEIS2
MYH10
NEDD4L
NR3C1
PAX6
PBX2
PDX1
PIN1
PKNOX1
POU2F1
SMARCD3
UBC
14 interacting genes:
CREBBP
EMX1
EP300
FOXO1
GMNN
GNG13
HMGB1
MEIS1
PBX1
POLR3D
PTPN6
SIRT2
SNAPC1
SPI1
Entrez ID
5087
3206
HPRD ID
08889
00845
Ensembl ID
ENSG00000185630
ENSG00000253293
Uniprot IDs
A8K5V0
P40424
Q53YC7
P31260
PDB IDs
1B72
1PUF
Enriched GO Terms of Interacting Partners
?
Pattern Specification Process
Chromatin
Regionalization
Anterior/posterior Pattern Specification
Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Animal Organ Morphogenesis
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Sequence-specific Double-stranded DNA Binding
Anatomical Structure Morphogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Skeletal System Morphogenesis
Embryonic Morphogenesis
Regulation Of RNA Metabolic Process
Embryonic Organ Morphogenesis
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Embryonic Skeletal System Morphogenesis
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Nucleus
Nucleoplasm
Animal Organ Development
Regulation Of Metabolic Process
Proximal/distal Pattern Formation
Developmental Process
Embryonic Skeletal System Development
Skeletal System Development
Sequence-specific DNA Binding
Chromatin Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Cellular Developmental Process
Embryonic Limb Morphogenesis
Gland Development
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Myeloid Cell Differentiation
DNA-binding Transcription Factor Binding
Chromatin Binding
Positive Regulation Of Innate Immune Response
Histone H3K27 Acetyltransferase Activity
Megakaryocyte Development
Regulation Of Innate Immune Response
Positive Regulation Of Defense Response
Transcription Regulator Complex
Histone H3K18 Acetyltransferase Activity
N-terminal Peptidyl-lysine Acetylation
Peptide Lactyltransferase (CoA-dependent) Activity
Nucleus
Protein Acetylation
Regulation Of Myeloid Progenitor Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Developmental Process
Positive Regulation Of Binding
Regulation Of Oligodendrocyte Progenitor Proliferation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Hemopoiesis
Positive Regulation Of Immune Response
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Chromatin
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Binding
Regulation Of Immune System Process
Damaged DNA Binding
Transcription Corepressor Activity
Regulation Of RNA Metabolic Process
Activation Of Innate Immune Response
Developmental Process
Myeloid Cell Development
Regulation Of Cell Differentiation
Regulation Of Hemopoiesis
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Lymphocyte Differentiation
STAT Family Protein Binding
Regulation Of Cell Population Proliferation
Lymphocyte Activation
Sequence-specific DNA Binding
Positive Regulation Of RNA Biosynthetic Process
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Tagcloud (Intersection)
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