PBX1 and HOXA10

Number of citations of the paper that reports this interaction (PMID 12145285)
12

Data Source:
HPRD (in vivo)

		PBX1	HOXA10
Gene Name		pre-B-cell leukemia homeobox 1	homeobox A10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Histone Deacetylase Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Transcription, DNA-templated Steroid Biosynthetic Process Sex Differentiation Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Maintenance Embryonic Hemopoiesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Thymus Development Embryonic Skeletal System Development	Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Uterus Development
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Breast cancer (prognosis) ( 23319801) Height ( 20966902)	Dental caries ( 23259602)
Protein-Protein Interactions		24 interactors: CREBBP HOXA1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB7 HOXB8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PKNOX1 POU2F1 SMARCD3	12 interactors: CREBBP EMX1 EP300 FOXO1 GMNN MEIS1 PBX1 POLR3D PTPN6 SIRT2 SNAPC1 SPI1
Entrez ID		5087	3206
HPRD ID		08889	00845
Ensembl ID		ENSG00000185630	ENSG00000253293
Uniprot IDs		A8K5V0 H0YLB0 P40424 Q53YC7	P31260
PDB IDs		1B72 1PUF
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Embryonic Morphogenesis RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Pattern Specification Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Anterior/posterior Pattern Specification Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Organ Development Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Developmental Process Organ Morphogenesis Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Anatomical Structure Development Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Skeletal System Development System Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Skeletal System Morphogenesis Embryonic Limb Morphogenesis Embryonic Organ Development Negative Regulation Of Myeloid Cell Differentiation	Immune System Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Nitrogen Compound Metabolic Process Cell Development Protein Acetylation Negative Regulation Of Cell Differentiation N-terminal Peptidyl-lysine Acetylation Stem Cell Maintenance Positive Regulation Of Transcription, DNA-templated Innate Immune Response Organ Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Morphogenesis Gene Expression Multicellular Organismal Development Stem Cell Development Regulation Of Gene Expression Peptidyl-lysine Modification Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Positive Regulation Of Type I Interferon Production Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation N-terminal Protein Amino Acid Acetylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune Response Developmental Process Regulation Of Type I Interferon Production Negative Regulation Of Gene Expression System Development Defense Response
Tagcloud ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	contrary coordination definitive drives e2 elevate epigenetic eralpha ere ere1 ere2 eres extensively h3k4 haematopoiesis homeobox knockdown leukaemia lineage methylase mll mll1 much oestrogen recruiting start suppresses transcriptionally way
Tagcloud (Difference) ?		4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop	contrary coordination definitive drives e2 elevate epigenetic eralpha ere ere1 ere2 eres extensively h3k4 haematopoiesis homeobox knockdown lineage methylase mll mll1 much oestrogen recruiting start suppresses transcriptionally way
Tagcloud (Intersection) ?		leukaemia