ALDH7A1 and EPS8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		ALDH7A1	EPS8
Description		aldehyde dehydrogenase 7 family member A1	EGFR pathway substrate 8, signaling adaptor
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Extracellular Exosome	Cytoplasm Plasma Membrane Brush Border Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity L-aminoadipate-semialdehyde Dehydrogenase Activity Protein Binding Betaine-aldehyde Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding	Actin Binding Protein Binding Small GTPase Binding
	Biological Process	Aldehyde Metabolic Process Sensory Perception Of Sound Glycine Betaine Biosynthetic Process From Choline Choline Catabolic Process	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Choline catabolism Lysine catabolism	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		NADH Artenimol
Diseases
GWAS		Colorectal cancer ( 30529582) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Metabolite levels ( 23823483) Osteoporosis ( 20072603)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		6 interacting genes: APP EPS8 LCN2 MYG1 OGT RECQL5	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		501	2059
HPRD ID		00124	02563
Ensembl ID		ENSG00000164904	ENSG00000151491
Uniprot IDs		P49419	B4E3T6 Q12929
PDB IDs		2J6L 4X0T 4X0U 4ZUK 4ZUL 4ZVW 4ZVX 4ZVY 6O4B 6O4C 6O4D 6O4E 6O4F 6O4G 6O4H 6O4I 6O4K 6O4L 6U2X 6V0Z	2E8M 7TZK
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Response To Interleukin-1 Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Adult Locomotory Behavior Cellular Response To Oxygen-containing Compound Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Response To Nerve Growth Factor Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Response To Amyloid-beta Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Reactive Oxygen Species Metabolic Process Locomotory Behavior Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Hippocampal Neuron Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Acetylcholine Receptor Activator Activity Response To Peptide Response To Cytokine Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Positive Regulation Of Cold-induced Thermogenesis Mitotic DNA-templated DNA Replication PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Growth Cone Memory Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Protein-containing Complex Assembly Response To Monosaccharide Siderophore Transport Protein O-acetylglucosaminyltransferase Activity	Epidermal Growth Factor Receptor Signaling Pathway Filopodium ERBB Signaling Pathway Protein Tyrosine Kinase Activator Activity Supramolecular Fiber Organization Actin Filament Organization Symbiont Entry Into Host Cell Ephrin Receptor Binding Actin Filament Bundle Organization Actin Filament Bundle Assembly Shc-EGFR Complex Focal Adhesion Enzyme-linked Receptor Protein Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Phosphotyrosine Residue Binding Biological Process Involved In Interaction With Host Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process Schwann Cell Development Ruffle SH3 Domain Binding Cellular Response To Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Epidermal Growth Factor Binding ERBB2 Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Response To Platelet-derived Growth Factor Neuregulin Binding Integrin Complex C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Response To Growth Factor Wound Healing, Spreading Of Cells Response To Activity Neurotrophin TRKA Receptor Binding Endocytosis Insulin Receptor Signaling Pathway Integrin Binding Virus Receptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Heterotypic Cell-cell Adhesion Actin-based Cell Projection Cellular Developmental Process Import Into Cell Schaffer Collateral - CA1 Synapse Ruffle Membrane Integrin-mediated Signaling Pathway Lamellipodium
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