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NRAS and RACGAP1
Number of citations of the paper that reports this interaction (PubMedID
10655059
)
0
Data Source:
HPRD
(in vitro)
NRAS
RACGAP1
Description
NRAS proto-oncogene, GTPase
Rac GTPase activating protein 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Extracellular Exosome
Tertiary Granule Membrane
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Spindle
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Membrane
Midbody
Cytoplasmic Vesicle
Cleavage Furrow
Spindle Midzone
Extracellular Exosome
Mitotic Spindle
Flemming Body
Centralspindlin Complex
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Protein-containing Complex Binding
GTPase Activator Activity
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Microtubule Binding
Zinc Ion Binding
Lipid Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Alpha-tubulin Binding
Gamma-tubulin Binding
Metal Ion Binding
Beta-tubulin Binding
Biological Process
MAPK Cascade
Positive Regulation Of Endothelial Cell Proliferation
Signal Transduction
Ras Protein Signal Transduction
Mitotic Cytokinesis
Actomyosin Contractile Ring Assembly
Monoatomic Ion Transport
Signal Transduction
Rho Protein Signal Transduction
Spermatogenesis
Neuroblast Proliferation
Cell Differentiation
Erythrocyte Differentiation
Positive Regulation Of Cytokinesis
Regulation Of Embryonic Development
Regulation Of Small GTPase Mediated Signal Transduction
Mitotic Spindle Midzone Assembly
Cell Division
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Sulfate Transmembrane Transport
Pathways
SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Signalling to RAS
p38MAPK events
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Insulin receptor signalling cascade
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS processing
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by RAS GAP mutants
Signaling by RAS GTPase mutants
MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RAC3 GTPase cycle
Kinesins
Drugs
Diseases
Adrenal carcinoma
Acute myeloid leukemia (AML)
Oral cancer
Multiple myeloma
Malignant melanoma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Hepatocellular carcinoma
Thyroid cancer
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Adult body size (
32376654
)
Autism (
24189344
)
Interacting Genes
48 interacting genes:
ACVR1
AKT1
ALDOB
AOPEP
ARAF
ARHGAP4
BCL2
CCDC180
CORO2A
CYLC2
DNAJB1
EEF1A1
FANCC
FBP2
FRAT2
HEMGN
HRAS
ITCH
LEF1
LZTR1
MAPK3
MAPKAP1
MTOR
NEDD4
PIK3CA
PIK3CG
PLCE1
PPP2CB
RACGAP1
RAF1
RAP1GDS1
RASGRP2
RASSF5
RGL2
RGL3
RPS20
SFRP4
SHOC2
SMAD1
SMAD4
SMURF2
SRI
STX17
TDRD7
TRMO
WDR76
XPA
ZDHHC9
32 interacting genes:
AURKB
BYSL
CDK1
CDK3
CHN2
ECT2
HIF1A
KIF23
MAP3K10
MAP3K4
MORF4L1
MPRIP
NRAS
PLK1
PPP2CA
PPP2R5E
PRC1
PRSS23
PTPA
RAC1
RND2
SH3RF1
SLC16A10
SLC26A8
TANK
TRAF3IP3
TUBA4A
TUBG1
TXNDC11
VAV1
YWHAB
YWHAG
Entrez ID
4893
29127
HPRD ID
01273
05402
Ensembl ID
ENSG00000213281
ENSG00000161800
Uniprot IDs
P01111
Q5U091
B2RE34
Q9H0H5
PDB IDs
2N9C
3CON
5UHV
6E6H
6MPP
6ULI
6ULK
6ULN
6ULR
6UON
6WGH
6ZIO
6ZIR
6ZIZ
7F68
7OW3
7OW4
7OW5
7OW6
7PB2
8TBI
8VM2
2OVJ
3W6R
3WPQ
3WPS
4B6D
5C2J
5C2K
Enriched GO Terms of Interacting Partners
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Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Intracellular Signaling Cassette
Insulin Receptor Signaling Pathway
Signal Transduction
Regulation Of Signal Transduction
Cytosol
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytoplasm
Regulation Of Small GTPase Mediated Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Population Proliferation
Cell Surface Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
ERBB Signaling Pathway
Ras Protein Signal Transduction
Positive Regulation Of Cell Migration
BMP Signaling Pathway
MAPK Cascade
Positive Regulation Of Cell Motility
Anoikis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Cellular Component Organization
Channel Inhibitor Activity
Programmed Cell Death
Cellular Response To Insulin Stimulus
Regulation Of Protein Catabolic Process
Regulation Of Autophagy
Cell Death
Small GTPase-mediated Signal Transduction
Regulation Of Ras Protein Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Gland Development
Negative Regulation Of Autophagy
Protein Serine/threonine Kinase Activity
Regulation Of Cell Growth
Lymphocyte Proliferation
Schwann Cell Development
Spindle Microtubule
Intracellular Signal Transduction
Spindle
Regulation Of Cytokinesis
Mitotic Spindle Midzone Assembly
Midbody
Spindle Midzone Assembly
Protein Phosphatase Type 2A Complex
Mitotic Spindle Elongation
Microtubule Cytoskeleton Organization Involved In Mitosis
Nucleotide Binding
Mitotic Cell Cycle
Signal Transduction
Mitotic Cytokinesis
Microtubule Cytoskeleton
Regulation Of Protein Localization To Nucleus
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Centralspindlin Complex
Microtubule-based Process
Cytosol
Microtubule Cytoskeleton Organization
Cell Division
Regulation Of Cell Division
Regulation Of Protein Modification Process
Cytoskeleton-dependent Cytokinesis
Mitotic Spindle Organization
Spindle Elongation
Cytoskeleton
Protein Serine Kinase Activity
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Positive Regulation Of Protein Modification Process
MAPK Cascade
Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Cytokinesis
Regulation Of Phosphorus Metabolic Process
Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Mitotic Sister Chromatid Segregation
Intracellular Signaling Cassette
Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Regulation Of Intracellular Signal Transduction
Phosphorylation-dependent Protein Binding
Cell Cycle G2/M Phase Transition
Protein Kinase Binding
Mitotic Nuclear Membrane Disassembly
Mitotic Spindle Midzone
Regulation Of Protein Import Into Nucleus
Regulation Of Protein Localization
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Tagcloud (Intersection)
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