NRAS and PLCE1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NRAS	PLCE1
Description		NRAS proto-oncogene, GTPase	phospholipase C epsilon 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Extracellular Exosome Tertiary Granule Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Enzyme Binding Small GTPase Binding Metal Ion Binding
	Biological Process	MAPK Cascade Positive Regulation Of Endothelial Cell Proliferation Signal Transduction Ras Protein Signal Transduction	Lipid Metabolic Process Diacylglycerol Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol
Pathways		SOS-mediated signalling Activation of RAS in B cells Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signaling by SCF-KIT Signalling to RAS p38MAPK events p38MAPK events GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling SHC-related events triggered by IGF1R FCERI mediated MAPK activation NCAM signaling for neurite out-growth Ras activation upon Ca2+ influx through NMDA receptor VEGFR2 mediated cell proliferation CD209 (DC-SIGN) signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease Regulation of RAS by GAPs RAF activation RAF/MAP kinase cascade MAP2K and MAPK activation Negative regulation of MAPK pathway Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions RAS signaling downstream of NF1 loss-of-function variants Paradoxical activation of RAF signaling by kinase inactive BRAF Insulin receptor signalling cascade PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAS signaling Activated NTRK2 signals through RAS Erythropoietin activates RAS Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK3 signals through RAS FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Estrogen-stimulated signaling through PRKCZ RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by RAS GAP mutants Signaling by RAS GTPase mutants	Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases		Adrenal carcinoma Acute myeloid leukemia (AML) Oral cancer Multiple myeloma Malignant melanoma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Hepatocellular carcinoma Thyroid cancer Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Adult body size ( 32376654) Autism ( 24189344)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cataracts ( 34127677) Coronary artery disease ( 29212778) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 21909115 27841878 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Glucose homeostasis traits ( 25524916) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertension ( 31879980 21909115) Language functional connectivity ( 34929384) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Migraine ( 27322543 27182965) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Optic cup area ( 31798171) Personality traits in bipolar disorder ( 21368711) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Platelet reactivity in response to clopidogrel treatment ( 32472697) Plateletcrit ( 27863252 32888494) Pulse pressure ( 28739976 27841878 30578418) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976 21909115 30578418 27841878 27618452) Vertical cup-disc ratio ( 31798171 25241763) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)
Interacting Genes		48 interacting genes: ACVR1 AKT1 ALDOB AOPEP ARAF ARHGAP4 BCL2 CCDC180 CORO2A CYLC2 DNAJB1 EEF1A1 FANCC FBP2 FRAT2 HEMGN HRAS ITCH LEF1 LZTR1 MAPK3 MAPKAP1 MTOR NEDD4 PIK3CA PIK3CG PLCE1 PPP2CB RACGAP1 RAF1 RAP1GDS1 RASGRP2 RASSF5 RGL2 RGL3 RPS20 SFRP4 SHOC2 SMAD1 SMAD4 SMURF2 SRI STX17 TDRD7 TRMO WDR76 XPA ZDHHC9	5 interacting genes: HRAS KIT LIMS1 NRAS PPP1R3B
Entrez ID		4893	51196
HPRD ID		01273	07087
Ensembl ID		ENSG00000213281	ENSG00000138193
Uniprot IDs		P01111 Q5U091	A0A8I5KXT2 B7ZM61 Q9P212
PDB IDs		2N9C 3CON 5UHV 6E6H 6MPP 6ULI 6ULK 6ULN 6ULR 6UON 6WGH 6ZIO 6ZIR 6ZIZ 7F68 7OW3 7OW4 7OW5 7OW6 7PB2 8TBI 8VM2	2BYE 2BYF 2C5L
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Intracellular Signaling Cassette Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cytosol Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoplasm Regulation Of Small GTPase Mediated Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Population Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Cell Migration BMP Signaling Pathway MAPK Cascade Positive Regulation Of Cell Motility Anoikis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Regulation Of Cellular Component Organization Channel Inhibitor Activity Programmed Cell Death Cellular Response To Insulin Stimulus Regulation Of Protein Catabolic Process Regulation Of Autophagy Cell Death Small GTPase-mediated Signal Transduction Regulation Of Ras Protein Signal Transduction Cellular Response To Peptide Hormone Stimulus Gland Development Negative Regulation Of Autophagy Protein Serine/threonine Kinase Activity Regulation Of Cell Growth Lymphocyte Proliferation Schwann Cell Development	Regulation Of Epithelial Cell Proliferation Regulation Of Neuronal Synaptic Plasticity GDP Binding G Protein Activity Regulation Of Long-term Neuronal Synaptic Plasticity Ras Protein Signal Transduction Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly GTPase Complex Calcium:proton Antiporter Activity Negative Regulation Of Glycogen Catabolic Process [phosphorylase] Phosphatase Activity Phospholipase C Activator Activity Kit Signaling Pathway Positive Regulation Of Small Intestine Smooth Muscle Contraction Melanocyte Migration Regulation Of Generation Of Precursor Metabolites And Energy Calcium Export From The Mitochondrion Regulation Of Cell Population Proliferation Mast Cell Differentiation Mast Cell Chemotaxis Mitochondrial Potassium Ion Transmembrane Transport Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Metabolic Process Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Mast Cell Proliferation Mast Cell Proliferation Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Cell Projection Assembly Cell Death Regulation Of Synaptic Plasticity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Oncogene-induced Cell Senescence Negative Regulation Of Programmed Cell Death Programmed Cell Death MAPK Cascade Myeloid Progenitor Cell Differentiation Tongue Development Cell-cell Junction Germ Cell Migration Hematopoietic Stem Cell Migration Regulation Of Mast Cell Proliferation Mast Cell Migration Glycogen Granule Regulation Of Glycogen Catabolic Process
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