NRAS and ZDHHC9

Number of citations of the paper that reports this interaction (PubMedID 38182928)
0

Data Source:
BioGRID (enzymatic study)

		NRAS	ZDHHC9
Description		NRAS proto-oncogene, GTPase	zDHHC palmitoyltransferase 9
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Extracellular Exosome Tertiary Granule Membrane	Golgi Membrane Palmitoyltransferase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Ras Palmitoyltransferase Activity
	Biological Process	MAPK Cascade Positive Regulation Of Endothelial Cell Proliferation Signal Transduction Ras Protein Signal Transduction	MAPK Cascade Negative Regulation Of T-helper 1 Type Immune Response Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Virion Attachment To Host Cell ERAD Pathway Host-mediated Activation Of Viral Process Protein Maturation Positive Regulation Of Pyroptotic Inflammatory Response CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Pyroptotic Cell Death
Pathways		SOS-mediated signalling Activation of RAS in B cells Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signaling by SCF-KIT Signalling to RAS p38MAPK events p38MAPK events GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling SHC-related events triggered by IGF1R FCERI mediated MAPK activation NCAM signaling for neurite out-growth Ras activation upon Ca2+ influx through NMDA receptor VEGFR2 mediated cell proliferation CD209 (DC-SIGN) signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease Regulation of RAS by GAPs RAF activation RAF/MAP kinase cascade MAP2K and MAPK activation Negative regulation of MAPK pathway Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions RAS signaling downstream of NF1 loss-of-function variants Paradoxical activation of RAF signaling by kinase inactive BRAF Insulin receptor signalling cascade PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAS signaling Activated NTRK2 signals through RAS Erythropoietin activates RAS Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK3 signals through RAS FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Estrogen-stimulated signaling through PRKCZ RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by RAS GAP mutants Signaling by RAS GTPase mutants	RAS processing Maturation of spike protein
Drugs
Diseases		Adrenal carcinoma Acute myeloid leukemia (AML) Oral cancer Multiple myeloma Malignant melanoma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Hepatocellular carcinoma Thyroid cancer Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Adult body size ( 32376654) Autism ( 24189344)	Refractive error ( 32231278)
Interacting Genes		48 interacting genes: ACVR1 AKT1 ALDOB AOPEP ARAF ARHGAP4 BCL2 CCDC180 CORO2A CYLC2 DNAJB1 EEF1A1 FANCC FBP2 FRAT2 HEMGN HRAS ITCH LEF1 LZTR1 MAPK3 MAPKAP1 MTOR NEDD4 PIK3CA PIK3CG PLCE1 PPP2CB RACGAP1 RAF1 RAP1GDS1 RASGRP2 RASSF5 RGL2 RGL3 RPS20 SFRP4 SHOC2 SMAD1 SMAD4 SMURF2 SRI STX17 TDRD7 TRMO WDR76 XPA ZDHHC9	3 interacting genes: CREB3 HRAS NRAS
Entrez ID		4893	51114
HPRD ID		01273	06759
Ensembl ID		ENSG00000213281	ENSG00000188706
Uniprot IDs		P01111 Q5U091	Q9Y397
PDB IDs		2N9C 3CON 5UHV 6E6H 6MPP 6ULI 6ULK 6ULN 6ULR 6UON 6WGH 6ZIO 6ZIR 6ZIZ 7F68 7OW3 7OW4 7OW5 7OW6 7PB2 8TBI 8VM2	8HF3
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Intracellular Signaling Cassette Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cytosol Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoplasm Regulation Of Small GTPase Mediated Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Population Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Cell Migration BMP Signaling Pathway MAPK Cascade Positive Regulation Of Cell Motility Anoikis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Regulation Of Cellular Component Organization Channel Inhibitor Activity Programmed Cell Death Cellular Response To Insulin Stimulus Regulation Of Protein Catabolic Process Regulation Of Autophagy Cell Death Small GTPase-mediated Signal Transduction Regulation Of Ras Protein Signal Transduction Cellular Response To Peptide Hormone Stimulus Gland Development Negative Regulation Of Autophagy Protein Serine/threonine Kinase Activity Regulation Of Cell Growth Lymphocyte Proliferation Schwann Cell Development	GDP Binding G Protein Activity Golgi Membrane Ras Protein Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Deacetylase Activity Endoplasmic Reticulum Membrane GTPase Complex Positive Regulation Of Epithelial Cell Proliferation Golgi Apparatus Phospholipase C Activator Activity MAPK Cascade Small GTPase-mediated Signal Transduction GTPase Activity Regulation Of Cell Population Proliferation Intracellular Signal Transduction Chemotaxis CCR1 Chemokine Receptor Binding Release From Viral Latency Locomotion Oncogene-induced Cell Senescence GTP Binding Regulation Of Epithelial Cell Proliferation T-helper 1 Type Immune Response CAMP Response Element Binding Protein Binding Positive Regulation Of Ruffle Assembly Induction Of Positive Chemotaxis Positive Regulation Of Cell Migration Schwann Cell Development Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Protein Targeting To Membrane Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Positive Chemotaxis Regulation Of Protein Localization To Synapse Cellular Response To Gamma Radiation Defense Response To Protozoan Regulation Of Receptor Localization To Synapse Regulation Of Protein Targeting To Membrane Response To Protozoan Regulation Of Ruffle Assembly Regulation Of Monocyte Chemotaxis Protein-membrane Adaptor Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Integrated Stress Response Signaling Negative Regulation Of Apoptotic Process Fibroblast Proliferation
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