NRAS and SHOC2

Number of citations of the paper that reports this interaction (PMID 9674433)
37

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		NRAS	SHOC2
Gene Name		neuroblastoma RAS viral (v-ras) oncogene homolog	soc-2 suppressor of clear homolog (C. elegans)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Membrane Extracellular Vesicular Exosome	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	GTP Binding Protein Complex Binding	Protein Phosphatase Regulator Activity Protein Phosphatase Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Skeletal Muscle Tissue Development Leukocyte Migration Striated Muscle Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis	Ras Protein Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: ACVR1 ARHGAP4 BCL2 DNAJB1 EEF1A1 PIK3CA PIK3CG PLCE1 RACGAP1 RAF1 RAP1GDS1 RASGRP2 RASSF5 RGL2 RPS20 SHOC2 SMAD4 SMURF2 SRI	6 interactors: APP ERBB2IP HRAS KRAS NRAS RAF1
Entrez ID		4893	8036
HPRD ID		01273	04144
Ensembl ID		ENSG00000213281	ENSG00000108061
Uniprot IDs		P01111 Q5U091	Q9UQ13
PDB IDs		3CON
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Ras Protein Signal Transduction Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Ras Protein Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cardiovascular System Development Cellular Response To Organic Substance Regulation Of Growth Regulation Of Cell Growth Response To Organic Substance Endocardial Cell Differentiation Positive Regulation Of Hydrolase Activity Cell Activation Regulation Of Protein Phosphorylation Response To Wounding Cell Proliferation Cellular Metal Ion Homeostasis Positive Regulation Of GTPase Activity Platelet Activation Blood Coagulation Hemostasis Cellular Cation Homeostasis Regulation Of GTPase Activity Cellular Ion Homeostasis Metal Ion Homeostasis Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation BMP Signaling Pathway Stem Cell Development	Positive Regulation Of Rac Protein Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Visual Learning Visual Behavior Activation Of MAPKK Activity Associative Learning Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Blood Coagulation Hemostasis Learning Insulin Receptor Signaling Pathway Axonogenesis Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Synaptic Transmission, GABAergic Wound Healing Chemotaxis Response To Fibroblast Growth Factor Regulation Of Rac Protein Signal Transduction Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Response To Wounding Epithelial Tube Branching Involved In Lung Morphogenesis Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Learning Or Memory Positive Regulation Of Ras Protein Signal Transduction Fc Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Neuronal Synaptic Plasticity Activation Of Protein Kinase Activity Innate Immune Response Signal Transduction By Phosphorylation Neuron Projection Development Response To Insulin Cognition Positive Regulation Of Small GTPase Mediated Signal Transduction
Tagcloud ?		12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit	aortic associates biopsies cardiac cardiomyocytes clear clearly constriction decompensated died elucidated erbb2 erbin erk explored failing heart hearts homolog hypertrophy interacting isoproterenol modulating overload participates raf rapidly soc widely
Tagcloud (Difference) ?		12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit	aortic associates biopsies cardiac cardiomyocytes clear clearly constriction decompensated died elucidated erbb2 erbin erk explored failing heart hearts homolog hypertrophy interacting isoproterenol modulating overload participates raf rapidly soc widely
Tagcloud (Intersection) ?