SORT1

Gene Name		sortilin 1
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G-protein Coupled Nerve Growth Factor Binding
	Biological Process	Ossification Golgi To Endosome Transport Endocytosis G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organismal Development Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Chronic kidney disease ( 20383146) Coronary heart disease ( 21378988 21378990) LDL cholesterol ( 18193043 18193044 19060906 19060910 20686565) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Progranulin levels ( 21087763) Response to statin therapy ( 20339536)
Protein-protein Interactions		8 interactors: BDNF GGA1 GGA2 LRPAP1 NGF NGFR NTS SORCS1
Entrez ID		6272
HPRD ID		03910
Ensembl ID		ENSG00000134243
Uniprot IDs		Q99523
PDB IDs		3F6K 3G2U 3G2V
Enriched GO Terms of Interacting Partners?		Regulation Of Axonogenesis Circadian Rhythm Cellular Response To Nerve Growth Factor Stimulus Response To Electrical Stimulus Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Regulation Of Axon Extension Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Response To Anesthetic Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Fluoxetine Response To L-glutamate Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Nerve Development Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Regulation Of Stem Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Size Taste Bud Development Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Neuron Maturation Dendrite Extension Negative Regulation Of Hair Follicle Development Cellular Response To Norepinephrine Stimulus Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Hair Cycle Nerve Growth Factor Processing Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Apoptotic Process Axon Target Recognition Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Response To Norepinephrine Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Response To Ether Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Death Regulation Of Cysteine-type Endopeptidase Activity Cell Projection Morphogenesis
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