SORT1 and NTS

Number of citations of the paper that reports this interaction (PMID 9756851)
46

Data Source:
HPRD (in vivo, in vitro)

		SORT1	NTS
Gene Name		sortilin 1	neurotensin
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Transport Vesicle
	Molecular Function	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G-protein Coupled Nerve Growth Factor Binding	Neuropeptide Hormone Activity Protein Binding
	Biological Process	Ossification Golgi To Endosome Transport Endocytosis G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organismal Development Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity	Signal Transduction Regulation Of Blood Vessel Size
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Chronic kidney disease ( 20383146) Coronary heart disease ( 21378988 21378990) LDL cholesterol ( 18193043 18193044 19060906 19060910 20686565) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Progranulin levels ( 21087763) Response to statin therapy ( 20339536)
Protein-Protein Interactions		8 interactors: BDNF GGA1 GGA2 LRPAP1 NGF NGFR NTS SORCS1	9 interactors: ACE2 ARRB2 CPE MEP1A NLN NTSR1 NTSR2 PREP SORT1
Entrez ID		6272	4922
HPRD ID		03910	08878
Ensembl ID		ENSG00000134243	ENSG00000133636
Uniprot IDs		Q99523	P30990 Q6FH20
PDB IDs		3F6K 3G2U 3G2V	2LNE 2LNF 2LNG 2LYW 3F6K
Enriched GO Terms of Interacting Partners?		Regulation Of Axonogenesis Circadian Rhythm Cellular Response To Nerve Growth Factor Stimulus Response To Electrical Stimulus Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Regulation Of Axon Extension Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Response To Anesthetic Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Fluoxetine Response To L-glutamate Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Nerve Development Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Regulation Of Stem Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Size Taste Bud Development Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Neuron Maturation Dendrite Extension Negative Regulation Of Hair Follicle Development Cellular Response To Norepinephrine Stimulus Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Hair Cycle Nerve Growth Factor Processing Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Apoptotic Process Axon Target Recognition Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Response To Norepinephrine Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Response To Ether Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Death Regulation Of Cysteine-type Endopeptidase Activity Cell Projection Morphogenesis	Neuropeptide Signaling Pathway Proteolysis G-protein Coupled Receptor Signaling Pathway Peptide Hormone Processing Receptor Metabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Adult Locomotory Behavior Digestion Angiotensin-mediated Drinking Behavior Angiotensin Catabolic Process In Blood Behavior Peptide Metabolic Process Multicellular Organismal Protein Catabolic Process Adult Behavior Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Follicle-stimulating Hormone Signaling Pathway Insulin Processing Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organismal Protein Metabolic Process Hormone Metabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Receptor Biosynthetic Process Drinking Behavior Virion Attachment To Host Cell Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Lipoprotein Lipase Activity Plasma Membrane To Endosome Transport Cell Surface Receptor Signaling Pathway Glucose Import Brain Renin-angiotensin System Locomotory Behavior Protein Processing Insulin Metabolic Process Adhesion Of Symbiont To Host Cellular Amide Metabolic Process Regulation Of Hormone Levels Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-1 Beta Production Nerve Growth Factor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cardiac Left Ventricle Morphogenesis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Synaptic Transmission, Dopaminergic
Tagcloud ?		aaa acceptance adequately advances aneurysm avenues bioinformatics chances collaboration confirmatory considerable decade difficulty exploration focusing highlighted identification ldlr lrp1 millions necessity original owing powered progressed robustly unlock variant verified	acts autocrine cascades competing directed document embedded gxkkxxk homopolymeric localizes mediator mid motif mutagenesis nucleolin nucleolus paracrine parathyroid predict preservation pthrp representing ribonucleoprotein rna rnas salt secreted shared translated
Tagcloud (Difference) ?		aaa acceptance adequately advances aneurysm avenues bioinformatics chances collaboration confirmatory considerable decade difficulty exploration focusing highlighted identification ldlr lrp1 millions necessity original owing powered progressed robustly unlock variant verified	acts autocrine cascades competing directed document embedded gxkkxxk homopolymeric localizes mediator mid motif mutagenesis nucleolin nucleolus paracrine parathyroid predict preservation pthrp representing ribonucleoprotein rna rnas salt secreted shared translated
Tagcloud (Intersection) ?