SORT1 and NGF

Number of citations of the paper that reports this interaction (PubMedID 20159974)
72

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		SORT1	NGF
Description		sortilin 1	nerve growth factor
Image
GO Annotations	Cellular Component	Nucleus Lysosome Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm Cerebellar Climbing Fiber To Purkinje Cell Synapse	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytosol Synaptic Vesicle Axon Dendrite Endosome Lumen
	Molecular Function	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding	Enzyme Inhibitor Activity Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Peptidase Inhibitor Activity Death Receptor Agonist Activity
	Biological Process	Ossification Protein Targeting To Lysosome Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Cell Differentiation Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation D-glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Golgi To Lysosome Transport Maintenance Of Synapse Structure	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peripheral Nervous System Development Circadian Rhythm Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Nerve Development Neuron Projection Development Positive Regulation Of Protein Ubiquitination Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Collateral Sprouting Axon Extension Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Golgi Associated Vesicle Biogenesis	PLC-gamma1 signalling Signalling to RAS NGF processing NGF processing Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling PI3K/AKT activation PI3K/AKT activation Signalling to STAT3 NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs			Clenbuterol RI 624 Polaprezinc Fasinumab Oleandrin
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Appendicular lean mass ( 33097823) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 18193044 25961943 18193043 19060906 19060910 24097068 20686565 21347282) LDL cholesterol levels ( 26690388 28334899) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733) Metabolite levels ( 21909109) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Total cholesterol levels ( 28334899)	Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Dysmenorrheic pain ( 27454463) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Obstetric antiphospholipid syndrome ( 28424481) Pain medicine use during menstruation ( 29855537) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Red blood cell count ( 32888494) Schizophrenia ( 30285260) Systolic blood pressure ( 27841878)
Interacting Genes		17 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTF3 NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF	11 interacting genes: A2M CRYAB ITGA9 ITGB1 LRP1 MMP7 NGFR NTRK1 PLG SORCS3 SORT1
Entrez ID		6272	4803
HPRD ID		03910	08874
Ensembl ID		ENSG00000134243	ENSG00000134259
Uniprot IDs		Q99523	A0A346FYQ1 P01138
PDB IDs		3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H 8T8R 8T8S	1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7 6YW8
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin Binding Nerve Development Nerve Growth Factor Signaling Pathway Neurotrophin Receptor Activity Nerve Growth Factor Receptor Binding Endosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Endosome Membrane Positive Regulation Of Neuron Projection Development Positive Regulation Of Synapse Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Axonogenesis Early Endosome Membrane Enzyme-linked Receptor Protein Signaling Pathway Axon Mechanoreceptor Differentiation Regulation Of Nervous System Development Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cell Junction Assembly Dendrite Regulation Of Neuron Apoptotic Process Rhythmic Process Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Nervous System Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Nerve Growth Factor Binding Cellular Response To Nerve Growth Factor Stimulus Regulation Of Axonogenesis Signal Transduction Nervous System Development Early Endosome Response To Nerve Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synapse Assembly Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Regulation Of Signal Transduction Establishment Of Protein Localization To Plasma Membrane System Development Signaling Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development	Nerve Growth Factor Binding Cell Surface Integrin Alpha9-beta1 Complex Nerve Growth Factor Receptor Activity Neurotrophin Binding Integrin Binding Involved In Cell-matrix Adhesion Cellular Response To Amyloid-beta Synaptic Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse Modulation Of Chemical Synaptic Transmission Response To Amyloid-beta Signaling Receptor Activity Amyloid-beta Binding Negative Regulation Of Vasoconstriction Enzyme-linked Receptor Protein Signaling Pathway Nerve Growth Factor Signaling Pathway Protease Binding Neurotrophin TRK Receptor Signaling Pathway Apolipoprotein Binding Detection Of Temperature Stimulus Dendritic Spine Response To Temperature Stimulus System Process Integrin Complex Neurotrophin Signaling Pathway Plasma Membrane Myoblast Differentiation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Receptor Complex Regulation Of Cell Motility Regulation Of Locomotion Extracellular Matrix Disassembly Nerve Development Extracellular Matrix Organization Extracellular Structure Organization Vascular Process In Circulatory System Myoblast Fate Specification Learning Or Memory Coreceptor Activity Integrin Alpha7-beta1 Complex Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Antibacterial Peptide Secretion Neurotrophin P75 Receptor Binding Neurotensin Receptor Activity, Non-G Protein-coupled Cell Surface Receptor Signaling Pathway Endosome Membrane Platelet Alpha Granule Lumen
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